INSULIN

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H334：흡입 시 알레르기성 반응, 천식 또는 호흡 곤란 등을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P285：환기가 잘 되지 않는 곳에서는 호흡기 보호구를 착용하시오

  P304+P341：들이마신 경우,호흡이 어려운 경우 환자를 신선한 공기가 있는 곳으로 옮기고 호흡하기 편한 자세로 안정을 취하게 함

  P342+P311：호흡기 증상이 나타나면 의료기관(의사)의 진찰을 받으시오.

  P501：...에 내용물 / 용기를 폐기 하시오.

INSULIN 화학적 특성, 용도, 생산

• 화학적 성질

  Insulin is a relatively simple protein consisting of 51 amino acids arranged as two polypeptide chains, an α- chain and β-chain, connected by disulfide bonds; the latter are necessary to maintain tertiary structure and biological activity. Although the amino acid sequence and composition of animal insulins may differ slightly from those of human insulin, their biological actions are similar. Alteration of specific amino acid residues within the insulin molecule yields novel derivatives that vary in their pharmacokinetics and binding affinity for the insulin receptor. Some insulin analogues display mitogenic properties in addition to their metabolic effects.

• 용도

  Insulin is a peptide hormone regulating the metabolism of carbohydrates and fats. It is used in the treatment of those suffering from the diabetes type I and II metabolic disorders. Regulates the absorption of glucose from the blood to skeletal muscles and fat storage.

• Indications

  More than a century has passed since von Mering and Minkowski first demonstrated that pancreatectomized dogs exhibited signs and symptoms characteristic of diabetes mellitus. Shortly thereafter, Banting and Best used pancreatic extracts to reverse these symptoms in diabetic patients, thus providing a basis for establishing a cause-and-effect relationship between insulin deficiency and diabetes. Insulin was subsequently isolated, crystallized, and eventually synthesized in the laboratory. Insulin replacement therapy has been widely used in the clinical management of diabetes mellitus for more than 70 years. In 1982, recombinant DNA (rDNA) derived human insulin was first produced and is now widely used instead of insulin derived from beef or pork. More recently, insulin analogues have been produced that modulate the activity and rate of insulin action.

• 정의

  A polypeptide hormone having a molecular weight of 5733. It is formed in the islets of Langerhans located in the pancreas and was so named for this reason. Insulin is composed of 16 amino acids arranged in a coiled chain and crosslinked in several places

• 위험도

  Overdosage can be fatal.

• Pharmacology

  Insulin is usually administered subcutaneously. Depending on the type of insulin being administered, the rate of insulin absorption can be modulated by altering the polymerization of the insulin molecule (e.g., monomers, dimers, or hexamers). Intramuscular injections of insulin are used less often because absorption is more rapid. Being a polypeptide hormone, insulin is readily inactivated if administered orally. In emergencies, such as severe diabetic ketoacidosis, insulin can be given intravenously. Clinical studies are examining the efficacy and safety of inhaled insulin, which may be promising for some patients.
  Once insulin enters the circulation, its plasma halflife is less than 10 minutes. Hepatic insulinases destroy approximately 50% of circulating insulin, with the remainder degraded by circulating proteases. Therefore, only a relatively small amount of the total endogenous insulin secreted ever reaches the peripheral tissues. Although a number of tissues accumulate small amounts of insulin, the liver and kidney are the principal sites of hormone uptake and degradation. Insulin metabolism is accomplished both through the actions of an insulinspecific protease found in the cytosol of many tissues and by the reductive cleavage of the insulin disulfide bonds by glutathione–insulin transhydrogenase. In the kidney, insulin that undergoes glomerular filtration is almost completely reabsorbed and metabolized within the proximal convoluted tubules of the nephron.

• Clinical Use

  According to the DCCT and the UK Prospective Diabetes study, insulin and/or insulin analogues are the standard treatment for type 1, gestational, and some type 2 diabetes.

• 부작용

  Insulin Overdose and Diabetic Coma The most common and serious reaction to insulin therapy is hypoglycemia. It is important that patients with diabetes, especially those receiving insulin therapy, be able to recognize the signs and symptoms of hypoglycemia. Symptoms of hypoglycemia may be evident with a plasma glucose level at 60 to 80 mg/dL. Severe hypoglycemia can lead to convulsions and coma. Patients that vigorously attempt to achieve euglycemia to avoid various vascular complications risk increased frequency of hypoglycemic episodes. In the DCCT, the incidence of severe hypoglycemic reactions was threefold higher in the intensive insulin therapy group than in the conventional therapy group.

• 신진 대사

  Insulin degradation occurs primarily in the liver and kidney. Of that which is secreted from the pancreatic islet cells, 50% reaches the liver via the portal vein and undergoes disulfide bond cleavage catalyzed by glutathione insulin transhydrogenase (insulinase). This is followed by proteolytic degradation before entry into the general circulation. Insulin is filtered by the renal glomeruli and can then be reabsorbed or degraded by the tubules. At the tissue level, insulin degradation occurs to a limited extent at the cell surface.

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