AZIMILIDE

한글명:AZIMILIDE

카스 번호149908-53-2

상품명:AZIMILIDE

CBNumberCB0197878

분자식C23H28ClN5O3

포뮬러 무게457.95

MOL 파일149908-53-2.mol

화학적 성질

끓는 점	594.9±60.0 °C(Predicted)
밀도	1.32
저장 조건	2-8°C
용해도	<4.58mg/mL in DMSO
물리적 상태	가루
산도 계수 (pKa)	7.72±0.10(Predicted)

그림문자(GHS)

AZIMILIDE 화학적 특성, 용도, 생산

용도
Cardiac depressant (anti-arrhythmic).
일반 설명
Azimilide, E-1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione, is a class III agent that significantlyblocks the delayed rectifier potassium current,Iks, including the Ikr component. Its ability to block multichannelsmay be caused by a lack of the methane sulfonamidegroup that is common to other class III agents, whichselectively block the Ikr potassium current. It is believedthat blocking both Ikr and Iks potassium currents yields consistentclass III antiarrhythmic effects at any heart rate.
Clinical Use
Azimilde is another Class III antiarrhythmic agent structurally unrelated to any of the above agents. Azimilide is not available in the United States; it is only available in Europe. Following oral administration, the drug is completely absorbed, with no effect of food. Protein binding is 94%. It is metabolized in the liver to an active carboxylate metabolite, but its concentration in plasma is less than 5% of the parent compound. Thus, it is considered to be therapeutically inactive. Renal excretion is approximately 10%. Its elimination half-life is 3 to 4 days.
효소 저해제
This class ΙΙΙ antiarrhythmic drug and ion channel blocker (FW = 457.95 g/mol; CAS 149908-53-2), also known by the code name NE-10064 and systematic name, 1-({(E)-[5-(4-chlorophenyl)furan-2-yl]methylidene} amino)-3-[4-(4-methylpiperazin-1-yl)butyl]-imidazolidine-2,4-dione, blocks both the slow-activating IKs and rapidly activating IKr components of the delayed rectifier potassium current, distinguishing its action from conventional potassium channel blockers such as sotalol and dofetilide,which block only IKr. Azimilide prolongs the cardiac refractory period in a dose-dependent manner, as manifested by increases in action potential duration, QTc interval, and effective refractory period.

AZIMILIDE 준비 용품 및 원자재

AZIMILIDE 공급 업체

Send Inquriy