아세페론

아세페론 화학적 특성, 용도, 생산

• Originator

  Aceperone ,ZYF Pharm Chemical

• Manufacturing Process

  A mixture of 1-benzyl-4-(4-phenyl)-4-(acetaminomethyl)piperidine, 3-(4- fluorobenzoyl)propyl bromide, sodium bicarbonate and anhydrous acetone was stirred and heated under reflux. The resulting mixture was filtered while still hot, and the filtrate was concentrated to dryness under reduced pressure. The residue was washed with ether to give 1-benzyl-1-[3-(4-fiuorobenzoyl)propyl]- (4-phenyl-4-acetaminomethyl)piperidinium bromide.
  To a stirred mixture of thiophenol and 15% (W/W) aqueous sodium hydroxide was added the 1-benzyl-1-[3-(4-fluorobenzoyl)propyl]-(4-phenyl-4- acetaminomethyl)piperidinium bromide and the mixture was heated to 85°- 90°C for 2 h. After cooling, solid matter precipitated was collected by filtration and washed with water to give 1-[3-(4-fluorobenzoyl)propyl]-4- (acetaminomethyl)-4-phenylpiperidine, melting point 111°-112°C.

• Therapeutic Function

  Vasodilator, Antihypertensive, Neuroleptic

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