2-フェノキシエタノール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H319：強い眼刺激

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P337+P313：眼の刺激が続く場合：医師の診断/手当てを受けること。

2-フェノキシエタノール 価格

MSDS Information

• Ethylene glycol monophenyl ether

2-フェノキシエタノール 化学特性,用途語,生産方法

• 外観

  無色澄明の液体

• 定義

  本品は、次の化学式で表される芳香族エーテルアルコールである。

• 溶解性

  水に微溶 (2.7g/100ml)。有機溶剤に可溶。エタノールに極めて溶けやすく、水にややとけにくい。

• 解説

  C8H10O2(138.16)．2-フェノキシエタノールは，エチレングリコールモノフェニルエーテルともいう．フェノールとエチレンオキシド，またはフェノキシドとエチレンクロロヒドリンとの反応で得られる．融点13 ℃，沸点245 ℃．d₄²⁰"1.11．n_D²⁰"1.534．有機合成原料のほか，香料の保留剤，殺菌剤や昆虫の防除剤として利用される．森北出版「化学辞典（第2版）

• 無機性値/有機性値

  135/160

• 用途

  高沸点溶剤、有機合成原料。

• 用途

  溶剤（インキ、香料、農薬）

• 用途

  香料保留剤,殺菌剤,防虫剤,織物なっ染助剤,写真フィルム添加剤,塗料防カビ剤

• 合成

  フェノールとオキシラン（）やブロモエタノール、エチレンカーボネートと反応させることでヒドロキシエチル化が進行し合成される。

• 化粧品の成分用途

  防腐剤、殺菌剤、香料

• 効能

  消毒薬, 保存剤

• 説明

  Phenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds). Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.

• 化学的特性

  clear colorless liquid

• 特性

  Phenoxyethanol is a tried-and-tested preservative, which is welltolerated by the skin and has a low allergy risk. It can be used over a wide pH range. This means that other preservatives can lose their effectiveness if the product is not within the right pH range. It does not smell unpleasant or change the color of the product, which can be the case when using natural antimicrobial substances.

• 使用

  Phenoxyethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments. The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile.
  Phenoxyethanol is commonly used in cosmetics for its antibacterial and antifungal properties. It is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.Reactions to phenoxyethanol have rarely been reported. Three cases of CoU induced by phenoxyethanol in cosmetics have been reported.2-Phenoxyethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4-dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.The possibility of immunological IgE-mediated reaction could not be confirmed because specific IgE against 2-phenoxyethanol was negative.

• 調製方法

  Phenoxyethanol is prepared by treating phenol with ethylene oxide in an alkaline medium.

• 一般的な説明

  Colorless liquid with a pleasant odor. Density 1.02 g / cm3. An irritant.

• 空気と水の反応

  Oxidizes in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Water soluble.

• 反応プロフィール

  2-Phenoxyethanol may react violently with strong oxidizing agents. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. May initiate the polymerization of isocyanates and epoxides.

• 健康ハザード

  May cause moderate eye irritation and moderate corneal injury. Excessive exposure may cause skin irritation and hemolysis.

• 火災危険

  2-Phenoxyethanol is combustible.

• 使用用途

  フェノキシエタノールは、抗菌力を持つことから、様々なものに対する防腐剤として使用されることが多いです。

  特に化粧品での使用が多く、パラベンフリーなどが注目を集める中、安全性が高く多種の微生物に広く効果がある防腐剤として添加されることが多くなってきました。フェノキシエタノールが配合された化粧品は、香料などを使用していなくても花のような特徴的な香りがします。

  化粧品以外にも、防腐の効果を必要とするものは多数あります。医薬品、染料、インク、樹脂、、防虫剤、塗料の防黴剤、写真フィルムの添加剤、消毒薬など幅広い分野に使用されています。

• 応用例（製薬）

  Phenoxyethanol is an antimicrobial preservative used in cosmetics and topical pharmaceutical formulations at a concentration of 0.5–1.0%; it may also be used as a preservative and antimicrobial agent for vaccines.Therapeutically, a 2.2% solution or 2.0% cream has been used as a disinfectant for superficial wounds, burns, and minor infections of the skin and mucous membranes.
  Phenoxyethanol has a narrow spectrum of activity and is thus frequently used in combination with other preservatives,

• 工業用途

  2-Phenoxyethanol is used as a preservative in cosmetic formulations at a maximum concentration of 1.0%.
  2-Phenoxyethanol is a broad spectrum preservative which has excellent activity against a wide range of Gram negative and Gram positive bacteria, yeast and mould. It is also used as a solvent and, because of its properties as a solvent, it is used in many blends and mixtures with other preservatives.
  2-Phenoxyethanol is not registered as a food additive in the EU.
  Scognamiglio et al. (ref. 105) reported that 2-phenoxyethanol is a fragrance ingredient used in many fragrance mixtures (see discussion). An ester of 2-Phenoxyethanol, 2-Phenoxyethyl isobutyrate and 2-Phenoxyacetic acid, the main metabolite of 2-Phenoxyethanol, were mentioned in a WHO publication where 43 flavouring agents in food were evaluated (WHO 2003, AR4), however at intakes assessed to be very low in Europe (around 1 µg/kg bw/day).

• 接触アレルゲン

  Phenoxyethanol is an aromatic ether-alcohol used mainly as a preservative, mostly with methyldibromoglutaronitrile (in Euxyl K 400) or with parabens. Sensitization to this molecule is very rare.

• 副作用

  2-phenoxyethanol is a colorless or straw-colored oily liquid with slight solubility in water but soluble in ethanol and is used as an immersion anesthetic. This agent has bactericidal and fungicidal properties and has been used as a topical anesthetic. This agent can provide deep stages of anesthesia and is relatively inexpensive. Nevertheless, it has no other significant advantages over other drugs. Using 2-phenoxyethanol can elicit several side effects, such as decreased respiratory and heart rate, reduced blood pressure and blood oxygenation, alterations of blood parameters, and elevated plasma levels of adrenaline, glucose, and cortisol, as shown in bighead carp. In addition, sustained and prolonged exposure to 2-phenoxyethanol can cause neuropsychological syndrome in handlers[1].

• 安全性プロファイル

  Moderately toxic by ingestion and skin contact. A skin and severe eye irritant. Mutation data reported. Some glycol ethers have dangerous human reproductive effects. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes. To fight fEe, use CO2, dry chemical. Used as a solvent for ester-type resins. See also GLYCOL ETHERS.

• 安全性

  Phenoxyethanol produces a local anesthetic effect on the lips, tongue, and other mucous membranes. The pure material is a moderate irritant to the skin and eyes. In animal studies, a 10% v/v solution was not irritant to rabbit skin and a 2% v/v solution was not irritant to the rabbit eye.Long-term exposure to phenoxyethanol may result in CNS toxic effects similar to other organic solvents.Safety issues related to preservatives used in vaccines, including 2-phenoxyethanol have been reviewed.Contact urticaria has been reported upon exposure to 2-phenoxyethanol-containing cosmetics.
  The US FDA has recommended avoiding at least one topical product containing phenoxyethanol due to concerns over inadvertant exposure to nursing infants.
  LD₅₀ (rabbit, skin): 5 g/kg
  LD₅₀ (rat, oral): 1.26 g/kg

• 概要

  フェノキシエタノール（別称:エチレングリコールモノフェニルエーテル、フェニルセロソルブ）とは、とがエーテル結合した有機化合物です。沸点247℃、融点-2℃、密度1.10 g/cm3で、常温では無色の粘性液体、バラのような香りがするのが特徴です。

  水やアルコール類、など様々なものにも溶解しやすいことから取り扱いが容易といえます。緑茶にも含まれており、自然界にも存在する天然有機化合物です。常圧での引火点は121 ℃です。

• 貯蔵

  Aqueous phenoxyethanol solutions are stable and may be sterilized by autoclaving. The bulk material is also stable and should be stored in a well-closed container in a cool, dry place.

• 不和合性

  The antimicrobial activity of phenoxyethanol may be reduced by interaction with nonionic surfactants and possibly by absorption by polyvinyl chloride.The antimicrobial activity of phenoxyethanol against Pseudomonas aeruginosa may be reduced in the presence of cellulose derivatives (methylcellulose, sodium carboxymethylcellulose, and hypromellose (hydroxypropylmethylcellulose)).

• 規制状況(Regulatory Status)

  Included in the FDA Inactive Ingredients Database (topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
  Under European regulations for cosmetics (76/768/EEC), the maximum authorized concentration (MAC) of 2-phenoxyethanol is 1.0%.

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2-フェノキシエタノール スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

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