19-(3,6-ジヒドロ-3-メチル-6-オキソ-2H-ピラン-2-イル)-17-エチル-6-ヒドロキシ-3,5,7,9,11,15-ヘキサメチル-8-オキソ-2,10,12,16,18-ノナデカペンタエン酸

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H225：引火性の高い液体および蒸気

  H370：臓器の障害

• 注意書き

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

19-(3,6-ジヒドロ-3-メチル-6-オキソ-2H-ピラン-2-イル)-17-エチル-6-ヒドロキシ-3,5,7,9,11,15-ヘキサメチル-8-オキソ-2,10,12,16,18-ノナデカペンタエン酸 価格

19-(3,6-ジヒドロ-3-メチル-6-オキソ-2H-ピラン-2-イル)-17-エチル-6-ヒドロキシ-3,5,7,9,11,15-ヘキサメチル-8-オキソ-2,10,12,16,18-ノナデカペンタエン酸 化学特性,用途語,生産方法

• 使用

  Leptomycin B is the dominant and most studied member of the leptomycin class, isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1, a protein in the nuclear export sequence (NES). Proteins affected include c-Abl, cyclin B1, HIV-1 Rev, IκB, MPF, MAP/ERK, MDM2/p53, NF-κB/IκB7 and PKA. Leptomycin B inhibits export of many RNAs, e.g. COX-2 and c-FOS mRNA. Leptomycin B also shows antifungal and antibacterial and potent antitumour activities.

• 定義

  ChEBI: A leptomycin having a (2E,10E,12E,16Z,18E)-double bond configuration as well as an ethyl substituent at position 17.

• 一般的な説明

  Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo-cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, I?B, MPF, PKA and MEK.

• 生物活性

  Antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo .

• 作用機序

  The nuclear export inhibition mechanism involves the direct binding of Leptomycin B to exportin1, which blocks the binding of exportin1 to proteins containing the leucine-rich NES. Later, NES-exportin1 interaction was identified on a conserved region near cysteine-529 residue of human exportin1. This cysteine-529 residue on exportin1 provides LMB sensitivity because unsaturated γ-lactone in LMB undergoes a Michael-type reaction by the sulfhydryl group on cysteine residue. Once LMB is bound to exportin1, the NES-bearing nuclear export cargo fails to bind the receptor.

19-(3,6-ジヒドロ-3-メチル-6-オキソ-2H-ピラン-2-イル)-17-エチル-6-ヒドロキシ-3,5,7,9,11,15-ヘキサメチル-8-オキソ-2,10,12,16,18-ノナデカペンタエン酸 上流と下流の製品情報

19-(3,6-ジヒドロ-3-メチル-6-オキソ-2H-ピラン-2-イル)-17-エチル-6-ヒドロキシ-3,5,7,9,11,15-ヘキサメチル-8-オキソ-2,10,12,16,18-ノナデカペンタエン酸 生産企業

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19-(3,6-ジヒドロ-3-メチル-6-オキソ-2H-ピラン-2-イル)-17-エチル-6-ヒドロキシ-3,5,7,9,11,15-ヘキサメチル-8-オキソ-2,10,12,16,18-ノナデカペンタエン酸 スペクトルデータ(¹HNMR)

87081-35-4, 19-(3,6-ジヒドロ-3-メチル-6-オキソ-2H-ピラン-2-イル)-17-エチル-6-ヒドロキシ-3,5,7,9,11,15-ヘキサメチル-8-オキソ-2,10,12,16,18-ノナデカペンタエン酸 キーワード