オキシテトラサイクリン塩酸塩

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

オキシテトラサイクリン塩酸塩 価格

MSDS Information

• Oxytetracycline hydrochloride

オキシテトラサイクリン塩酸塩 化学特性,用途語,生産方法

• 外観

  黄色、結晶性粉末～粉末

• 溶解性

  水に溶けやすく、エタノールに溶けにくい。

• 用途

  動物用医薬品定量用の標準品。

• 効能

  抗生物質, 抗リケッチア, タンパク質合成阻害薬

• 商品名

  オキシテトラコーン (昭和薬品化工)

• 使用上の注意

  不活性ガス封入

• 説明

  Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). Oxytetracycline hydrochloride is used to study phagosome-lysosome (P-L) fusion in P388D1 cells and antibiotic susceptibilities of Mycoplasma bovis isolates.

• 化学的特性

  Yellow Crystalline Solid

• 使用

  Oxytetracycline hydrochloride is a salt prepared from oxytetracycline taking advantage of the basic dimethylamino group which protonates readily to form the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, oxytetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

• 一般的な説明

  Oxytetracycline hydrochloride appears as odorless fluffy yellow solid or yellow powder. Bitter taste. (NTP, 1992)

• 一般的な説明

  Early in 1950, Finlay et al.182 reported the isolation of oxytetracycline(Terramycin) from S. rimosus. This compoundwas soon identified as a chemical analog of chlortetracycline that showed similar antibiotic properties. The structureof oxytetracycline was elucidated by Hochstein et al.183 andthis work provided the basis for the confirmation of thestructure of the other tetracyclines.
  Oxytetracycline hydrochloride is a pale yellow, bitter,crystalline compound. The amphoteric base is only slightlysoluble in water and slightly soluble in alcohol. It is odorlessand stable in air but darkens on exposure to strong sunlight.The hydrochloride salt is a stable yellow powder that ismore bitter than the free base. It is much more soluble inwater, 1 g dissolving in 2 mL, and more soluble in alcoholthan the free base. Both compounds are inactivated rapidlyby alkali hydroxides and by acid solutions below pH 2. Bothforms of oxytetracycline are absorbed rapidly and equallywell from the digestive tract, so the only real advantage thefree base offers over the hydrochloride salt is that it is lessbitter. Oxytetracycline hydrochloride is also used for parenteraladministration (intravenously and intramuscularly).

• 空気と水の反応

  Oxytetracycline hydrochloride is hygroscopic. Water soluble. Undergoes slow hydrolysis in the presence of water. Concentrated aqueous solutions at neutral pH hydrolyze on standing.

• 反応プロフィール

  Oxytetracycline hydrochloride is sensitive to light. Oxytetracycline hydrochloride may be unstable at temperatures above 77° F. Oxytetracycline hydrochloride darkens on exposure to sunlight or to moist air above 194° F. Concentrated aqueous solutions at neutral pH hydrolyze on standing. Oxytetracycline hydrochloride undergoes hydrolysis in the presence of water. Oxytetracycline hydrochloride may be incompatible with alkalis.

• 火災危険

  Flash point data for Oxytetracycline hydrochloride are not available. Oxytetracycline hydrochloride is probably combustible.

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