臭化メチル ホマトロピン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

臭化メチル ホマトロピン 価格

臭化メチル ホマトロピン 化学特性,用途語,生産方法

• 外観

  白色～ほとんど白色粉末～結晶

• 効能

  散瞳薬, ムスカリン受容体拮抗薬

• 化学的特性

  White or almost white, crystalline powder or colourless crystals

• 使用

  Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. Methylhomatropine is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. Methylhomatropine does not cross the blood–brain barrier. Methylhomatropine is used, in addition to papaverine, as component of mild drugs that help "flush" the bile.

• 一般的な説明

  Homatropinemethylbromide, 3 -hydroxy-8-methyl-1 H,5 H-tropaniumbromide mandelate (Novatropine, Mesopin), occurs as a bitter,white, odorless powder and is affected by light. The compoundis readily soluble in water and alcohol but insoluble inether. The pH of a 1% solution is 5.9 and that of a 10% solutionis 4.5. Although a solution of the compound yields a precipitatewith alkaloidal reagents, such as mercuric potassiumiodide test solution, addition of alkali hydroxides or carbonatesdoes not cause the precipitate that occurs with nonquaternarynitrogen salts (e.g., atropine, homatropine).

• 臨床応用

  Homatropine methylbromide is transported poorly acrossthe blood-brain barrier because of its quaternary ammoniumgroup and, therefore, has far fewer stimulant properties thanatropine. It does have all the characteristic peripheralparasympathetic depressant properties of atropine and isused to reduce oversecretion and to relieve GI spasms.

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臭化メチル ホマトロピン スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、Raman)

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