1-(4-ヒドロキシ-3,5-ジヨードフェニル)-2-[(1-メチル-3-フェニルプロピル)アミノ]-1-プロパノール

1-(4-ヒドロキシ-3,5-ジヨードフェニル)-2-[(1-メチル-3-フェニルプロピル)アミノ]-1-プロパノール 化学特性,用途語,生産方法

• Originator

  Proclival,Houde,France,1970

• Manufacturing Process

  Buphenine is the starting material. See under the alternative name "Nylidrin" in this publication for synthesis.
  24 grams of buphenine hydrochloride are suspended in a mixture of 440 ml of 34% ammonia (specific gravity = 0.89) and 315 ml of water. 41 grams of iodine dissolved in 1,080 ml of 96% alcohol are added little by little, with good stirring. During this addition, effected in about 30 min, buphenine hydrochloride dissolves fairly rapidly, and then the diiodobuphenine precipitates out as a crystalline powder. Stirring is continued for a further hour. The precipitate is suction filtered, and then washed with water, with alcohol and with ether and is finally dried in vacuo in the exsiccator in the presence of phosphoric anhydride. Thus, about 23 grams of diiodobuphenine solvated with 1 mol of ethanol are obtained in the form of a microcrystalline white powder. MP (slow) = 185°C (dec.). MP (inst.): 212°C.

• Therapeutic Function

  Antihypertensive

1-(4-ヒドロキシ-3,5-ジヨードフェニル)-2-[(1-メチル-3-フェニルプロピル)アミノ]-1-プロパノール 上流と下流の製品情報

1-(4-ヒドロキシ-3,5-ジヨードフェニル)-2-[(1-メチル-3-フェニルプロピル)アミノ]-1-プロパノール 生産企業

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22103-14-6, 1-(4-ヒドロキシ-3,5-ジヨードフェニル)-2-[(1-メチル-3-フェニルプロピル)アミノ]-1-プロパノール キーワード