ブチルヒドロキシトルエン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P273：環境への放出を避けること。

  P391：漏出物を回収すること。

  P501：内容物/容器を．．．に廃棄すること。

ブチルヒドロキシトルエン 価格

MSDS Information

• 2,6-Di-tert-butyl-p-cresol

ブチルヒドロキシトルエン 化学特性,用途語,生産方法

• 外観

  白色〜わずかにうすい黄色, 結晶又は粒状

• 定義

  BHTは、ジブチルヒドロキシトルエンの表示名称である。本品は、次の化学式で表されるトルエン誘導体である。

• 溶解性

  エタノール及びアセトンに溶け、水にほとんど溶けない。

• 解説

  C15H24O(220.36)．2,6-ジ-t-ブチル-4-メチルフェノールは，略称BHT．p-クレゾールに2-メチルプロペンを硫酸存在下に反応させると得られる．融点71 ℃，沸点265 ℃．d₄²⁰"1.048．n_D⁷⁵"1.4895．水，アルカリに不溶，有機溶媒に可溶．食品，石油製品の酸化防止剤，香料，化粧品の添加剤，各種プラスチックの可塑剤に用いられる．食品衛生法により食品への使用が認められている．LD50 1700～1970 mg/kg(ラット，経口)．森北出版「化学辞典（第2版）

• 用途

  ゴム老化防止剤、酸化防止剤。

• 用途

  ジブチルヒドロキシトルエン定量用標準品。

• 用途

  有機ゴム薬品、老化防止剤、芳香族系有機薬品、食品添加物、酸化防止剤、香料中間体、化粧品原料

• 化粧品の成分用途

  酸化防止剤、香料

• 効能

  酸化防止剤

• 主な用途／役割

  ゴム系樹脂成分の接着剤の老化防止剤、ホットメルト系接着剤の酸化防止剤として使用される。

• 説明

  The antioxidant butylated hydroxytoluene is contained in food, adhesive glues, industrial oils and greases, including cutting fluids. Sensitization seems very rare.

• 化学的特性

  Butylated hydroxytoluene occurs as a white or pale yellow crystalline solid or powder with a faint characteristic phenolic odor.

• 天然物の起源

  Not reported found naturally.

• 使用

  Butylated Hydroxytoluene (BHT) is an antioxidant that functions similarly to butylated hydroxyanisole (BHA) but is less stable at high temperatures. It is also termed 2,6-di-tert-butyl-para-cresol. See Butylated Hydroxyanisole.

• 定義

  ChEBI: A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.

• 製造方法

  Butylated Hydroxytoluene is produced commercially by the alkylation of para-cresol with isobutylene. Butylated Hydroxytoluene is also produced by several western European manufacturers, production/processing plants in Germany, France, the Netherlands, United Kingdom and Spain.

• 調製方法

  Prepared by the reaction of p-cresol with isobutene.

• 一般的な説明

  White crystalline solid.

• 空気と水の反応

  Insoluble in water.

• 反応プロフィール

  Phenols, such as 2,6-Di-tert-butyl-4-methylphenol, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. May react with oxidizing materials.

• 健康ハザード

  2,6-Di-tert-butyl-p-cresol or Butylated Hydroxytoluene is of relatively low acute toxicity in animals, and there is no evidence of either acute or chronic effects among exposed workers.

• 火災危険

  2,6-Di-tert-butyl-4-methylphenol is combustible.

• 化学性质

  置換基を有する芳香族化合物

• 応用例（製薬）

  Butylated hydroxytoluene is used as an antioxidant in cosmetics, foods, and pharmaceuticals. It is mainly used to delay or prevent the oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.
  Butylated hydroxytoluene is also used at 0.5–1.0% w/w concentration in natural or synthetic rubber to provide enhanced color stability.
  Butylated hydroxytoluene has some antiviral activity and has been used therapeutically to treat herpes simplex labialis.

• 接触アレルゲン

  This antioxidant is contained in food, adhesive glues, industrial oils, and greases, including cutting fluids. Sensitization seems very rare.

• 発がん性

  The IARC has determined that there is limited evidence for the carcinogenicity of Butylated Hydroxytoluene in experimental animals.Butylated Hydroxytoluene has given primarily negative results in a large number of in vivo and in vitro genotoxic assays.No significant reproductive effects were observed in three-generation toxicity studies in mice administered up to 0.4% in the diet.6 The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for 2,6-ditert- butyl-p-cresol is 2mg/m3.

• 環境運命予測

  The metabolites of Butylated Hydroxytoluene can bind to cellular macromolecules, such as proteins and DNA, and cause toxicity.

• 職業ばく露

  DBPC is used as a food and feed additive, flavor, and packaging material; as an antioxidant in human foods and animal feeds. It is also used as an antioxidant to sta- bilize petroleum fuels, rubber and vinyl plastics.

• 安全性プロファイル

  Poison by intraperitoneal andintravenous routes. Moderately toxic by ingestion. Anexperimental teratogen. Other experimental reproductiveeffects. A human skin irritant. A skin and eye irritant.Questionable carcinogen with experimental carcinogenicand.

• 安全性

  Butylated hydroxytoluene is readily absorbed from the gastrointestinal tract and is metabolized and excreted in the urine mainly as glucuronide conjugates of oxidation products. Although there have been some isolated reports of adverse skin reactions, butylated hydroxytoluene is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.
  The WHO has set a temporary estimated acceptable daily intake for butylated hydroxytoluene at up to 125 μg/kg body-weight.
  Ingestion of 4 g of butylated hydroxytoluene, although causing severe nausea and vomiting, has been reported to be nonfatal.
  LD₅₀ (guinea pig, oral): 10.7 g/kg
  LD₅₀ (mouse, IP): 0.14 g/kg
  LD₅₀ (mouse, IV): 0.18 g/kg
  LD₅₀ (mouse, oral): 0.65 g/kg
  LD₅₀ (rat, oral): 0.89 g/kg

• 貯蔵

  Exposure to light, moisture, and heat causes discoloration and a loss of activity. Butylated hydroxytoluene should be stored in a wellclosed container, protected from light, in a cool, dry place.

• 輸送方法

  UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

• 純化方法

  Dissolve Butylated Hydroxytoluene in n-hexane at room temperature, then cool with rapid stirring, to -60o. The precipitate is separated, redissolved in hexane, and the process is repeated until the mother liquor is no longer coloured. The final product is stored under N2 at 0o [Blanchard J Am Chem Soc 82 2014 1960]. It has also been recrystallised from EtOH, MeOH, *benzene, n-hexane, methylcyclohexane or pet ether (b 60-80o), and is dried in a vacuum. [Beilstein 6 IV 3511.]

• 不和合性

  Butylated hydroxytoluene is phenolic and undergoes reactions characteristic of phenols. It is incompatible with strong oxidizing agents such as peroxides and permanganates. Contact with oxidizing agents may cause spontaneous combustion. Iron salts cause discoloration with loss of activity. Heating with catalytic amounts of acids causes rapid decomposition with the release of the flammable gas isobutene.

• 規制状況(Regulatory Status)

  GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

ブチルヒドロキシトルエン 上流と下流の製品情報

ブチルヒドロキシトルエン 生産企業

Global(1277)Suppliers

ブチルヒドロキシトルエン スペクトルデータ(¹HNMR、¹³CNMR、ESR、IR、IR1、IR2、IR3、MS、Raman)

128-37-0, ブチルヒドロキシトルエン キーワード