スロペネム

スロペネム 化学特性,用途語,生産方法

• 効能

  抗菌薬

• 説明

  Sulopenem is a parenteral penem that demonstrates high activity against Gram-positive, Gram-negative, and anaerobic bacteria. Since it is stable in relation to renal dehydropeptidase I, it does not require concomitant administration of an inhibitor of this enzyme.

• 使用

  Sulopenem is a β-Lactamase inhibitor which is used in treatment of microbial infections. It is an important reagent for many drugs synthesized against bacterial infections.

• 作用機序

  Sulopenem is one of the penems and, as such, interacts with penicillin-binding proteins (PBPs). From in vitro studies, sulopenem has shown a high affinity for PBP1a, 1b, 2, and 3 in E. coli.

• 薬物動態学

  When 1 g of CP-65,207 [containing 46.3% of S-isomer (sulopenem) and 53.7% of R-isomer] was administered by 10-minute intravenous infusions, the peak concentration of sulopenem in serum was 36.0 mg/ ml, its half-life was 52.8 minutes, and the area under the serum concentration-versus-time curve (AUC) from 0 to 8 hours was 21.0 mg/ml per hour.

スロペネム 生産企業

Global(43)Suppliers

120788-07-0, スロペネム キーワード