アセトヒドロキサム酸

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H360：生殖能または胎児への悪影響のおそれ

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

アセトヒドロキサム酸 価格

MSDS Information

• Acetohydroxamic acid

アセトヒドロキサム酸 化学特性,用途語,生産方法

• 外観

  白色～黄色, 結晶～結晶性粉末

• 溶解性

  水、エタノールに可溶:エーテルに不溶。

• 用途

  有機合成原料、ウレアーゼ阻害剤。

• 効能

  抗菌薬 (補助薬), ウレアーゼ阻害薬

• 使用上の注意

  不活性ガス封入。

• 説明

  Acetohydroxamic acid is a potent, non-competitive and irreversible inhibitor of bacterial urease (Ki≈lO^-7M). This enzyme, which is widely distributed in plants and bacteria, but not in mammalian cells, catalyzes the decomposition of urea to ammonia. Elevated urinary ammonia levels can reduce the antibacterial effectiveness of a number of agents. Thus, acetohydroxamic acid is useful as adjunctive therapy to decrease urinary ammonia and alkalinity in patients with chronic urea-splitting urinary infection. Such infections are a leading cause of recurring complications and death in paraplegics.

• 化学的特性

  White Crystalline Solid

• 使用

  Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. 2-Acetohydroxamic acid loaded floating microspheres forms an efficient drug delivery system for the treatment of Helicobacter pylori.
  Acetohydroxamic acid was used:
  to study the mechanism of complexation of iron (III) with acetohydroxamic acid.
  to study the inhibitory mechanism of lansoprazole and omeprazole on Helicobacter pyloni.
  in urease inhibition studies.
  for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile.
  Used in urease inhibition studies and for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile.

• 一般的な説明

  Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. 2-Acetohydroxamic acid loaded floating microspheres forms an efficient drug delivery system for the treatment of Helicobacter pylori.

• 副作用

  Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
  Call your doctor at once if you have:
  pounding heartbeats or fluttering in your chest;
  signs of a blood clot in your leg --pain, swelling, warmth, or redness in one or both legs;
  signs of a red blood cell disorder --pale or yellowed skin, dark colored urine, fever, confusion or weakness.
  Common side effects may include:
  headache during the first 2 days of treatment;
  skin rash, warmth, tingling or redness (especially if you drink alcohol while taking acetohydroxamic acid);
  upset stomach, nausea, loss of appetite;
  depressed mood;
  anxiety, tremors, nervousness;
  hair loss.

• 安全性プロファイル

  Moderately toxic by intraperitonealroute. An experimental teratogen. Other experimentalreproductive effects. Mutation data reported. When heatedto decomposition it emits toxic fumes of NOx.

アセトヒドロキサム酸 上流と下流の製品情報

アセトヒドロキサム酸 生産企業

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アセトヒドロキサム酸 スペクトルデータ(¹HNMR、IR1、IR2、MS、Raman)

546-88-3, アセトヒドロキサム酸 キーワード