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DL-メチオニン

DL-メチオニン 化学構造式
59-51-8
  • CAS番号.59-51-8
  • 化学名:DL-メチオニン
  • 别名:DL-メチオニン;(±)-2-アミノ-4-(メチルチオ)酪酸;rac-(R*)-2-アミノ-4-(メチルチオ)ブタン酸;rac-(R*)-2-[2-(メチルチオ)エチル]グリシン;2-アミノ-4-メチルチオ酪酸;D-メチオニン/L-メチオニン,(1:1);(±)-メチオニン;DL-2-アミノ-4-(メチルチオ)酪酸;DLメチオニン;DL‐メチオニン;メチオニン, DL-;D L - メチオニン;DL-メチオニン, 99%;DL-メチオニン (JAN)
  • 英語化学名:DL-Methionine
  • 英語别名:MET;L-MET;Dyprin;Amurex;Metion;Neston;Cynaron;Meonine;Metione;Urimeth
  • CBNumber:CB6208758
  • Molecular Formula:C5H11NO2S
  • Formula Weight:149.21
  • MOL File:59-51-8.mol
DL-メチオニン 物理性質
  • 融点  :284 °C (dec.)(lit.)
  • 比旋光度  :-1~+1°(D/20℃)(c=8,HCl)
  • 沸点  :306.9±37.0 °C(Predicted)
  • 比重(密度)  :1.34
  • FEMA  :3301 | D,L-METHIONINE
  • 屈折率  :1.5216 (estimate)
  • 貯蔵温度  : 0-6°C
  • 溶解性 :1 M HCl: 0.5 M at 20 °C, clear, colorless
  • 酸解離定数(Pka) :2.13(at 25℃)
  • 外見  :Crystals or Crystalline Powder
  • 色 :White
  • 光学活性 (optical activity) :[α]/D, c = 5 in 5 M HCl (inactive)
  • 水溶解度  :2.9 g/100 mL (20 ºC)
  • JECFA Number :1424
  • Merck  :14,5975
  • BRN  :636185
  • 安定性: :Stable. Incompatible with strong oxidising agents.
  • InChIKey :FFEARJCKVFRZRR-UHFFFAOYSA-N
  • CAS データベース :59-51-8(CAS DataBase Reference)
  • NISTの化学物質情報 :Methionine(59-51-8)
  • EPAの化学物質情報 :Methionine (59-51-8)
安全性情報
  • 主な危険性  :Xi
  • Rフレーズ  :33-36/37/38
  • Sフレーズ  :24/25-36-26
  • WGK Germany  :2
  • RTECS 番号 :PD0457000
  • F  :10-23
  • TSCA  :Yes
  • HSコード  :29304090

DL-メチオニン MSDS


Acimetion

DL-Methionine 化学特性,用途語,生産方法

  • 外観 白色, 結晶~粉末
  • 定義 本品は、次の化学式で表されるアミノ酸である。
  • 溶解性 水にやや溶けやすく、エタノール及びジエチルエーテルにほとんど溶けない。
  • 用途 医薬原料、強化剤、飼料添加物
  • 用途 アミノ酸研究用、D又はL-体の原料。
  • 化粧品の成分用途 ヘアコンディショニング剤、皮膚コンディショニング剤
  • 効能 尿酸性化薬
  • 説明 Methionine is an α-amino acid with the chemical formula HO2CCH(NH2)CH2CH2SCH3. This essential amino acid is classified as nonpolar. This amino-acid is coded by the initiation codon AUG which indicates mRNA's coding region where translation into protein begins.
  • 化学的特性 White, crystalline platelets or powder having a characteristic odor. One g dissolves in about 30 mL of water. It is soluble in dilute acids and in solutions of alkali hydroxides. It is very slightly soluble in alcohol, and practically insoluble in ether. It is optically inactive. The pH of a 1 in 100 solution is between 5.6 and 6.1. This substance may be prepared by addition of methanethiol to acrolein; by chemical conversion of methylthiopropionic aldehyde.
  • 化学的特性 d,l-Methionine has a characteristic odor. It is an essential amino acid and is also used as a nutrient and dietary supplement.
  • 化学的特性 White crystalline powder
  • 天然物の起源 High levels of methionine can be found in eggs, sesame seeds, Brazil nuts, fish, meats and some other plant seeds; methionine is also found in cereal grains. Most fruits and vegetables contain very little of it. Most legumes are also low in methionine. Racemic methionine is sometimes added as an ingredient to pet foods.
  • 使用 An essential nonpolar amino acid with oxidative stress defense properties
  • 使用 DL-Methionine is sometimes given as a supplement to dogs; it helps keep dogs from damaging grass by reducing the pH of the urine.
    Methionine is allowed as a supplement to organic poultry feed under the US certified organic program.
  • 製造方法 By addition of methanethiol to acrolein; by chemical conversion of methylthiopropionic aldehyde.
  • 定義 ChEBI: A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.
  • brand name Pedameth (Forest).
  • 生合成 As an essential amino acid, methionine is not synthesized de novo in humans, who must ingest methionine or methioninecontaining proteins. In plants and microorganisms, methionine is synthesized via a pathway that uses both aspartic acid and cysteine. First, aspartic acid is converted via β-aspartyl-semialdehyde into homoserine, introducing the pair of contiguous methylene groups. Homoserine converts to O-succinyl homoserine, which then reacts with cysteine to produce cystathionine, which is cleaved to yield homocysteine. Subsequent methylation of the thiol group by folates affords methionine. Both cystathionine-γ-synthase and cystathionine- β-lyase require pyridoxyl-5′-phosphate as a cofactor, whereas homocysteine methyltransferase requires vitamin B12 as a cofactor.
  • Biotechnological Production DL-Methionine is the second amino acid that is almost exclusively manufactured by chemical synthesis. The process used today was originally developed by Werner Schwarze at Degussa in the 1940s, and has been continually improved and refined since. Today DL-methionine is manufactured in several plants, each with a capacity of more than 100,000 tonnes. To operate the process on an industrial scale also requires back-integration into the key hazardous raw materials acrolein, methyl mercaptan, and hydrogen cyanide. After the formation of the hydantoin, the key step is alkaline hydrolysis of the hydantoin, to produce methionine directly in up to 95 % yield based on acrolein.
  • 生物学の機能 Together with cysteine, methionine is one of two sulfurcontaining proteinogenic amino acids. Its derivative S-adenosyl methionine (SAM) serves as a methyl donor. Methionine is an intermediate in the biosynthesis of cysteine, carnitine, taurine, lecithin, phosphatidylcholine, and other phospholipids. Improper conversion of methionine can lead to atherosclerosis.
    This amino acid is also used by plants for synthesis of ethylene. The process is known as the Yang Cycle or the methionine cycle.
    Methionine is one of only two amino acids encoded by a single codon (AUG) in the standard genetic code (tryptophan, encoded by UGG, is the other). The codon AUG is also the most common eukaryote "Start" message for a ribosome that signals the initiation of protein translation from mRNA when the AUG codon is in a Kozak consensus sequence. As a consequence, methionine is often incorporated into the N-terminal position of proteins in eukaryotes and archaea during translation, although it can be removed by post-translational modification. In bacteria, the derivative Nformylmethionine is used as the initial amino acid.
  • 安全性プロファイル Moderately toxic by ingestion and other routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx. See also 1-METHIONINE.
  • 純化方法 Crystallise it from hot water or EtOH. Also purify it by dissolving it in H2O and passing through an Amberlite IR-120 resin (NH4+ form). The eluate is concentrated and then passed through Amberlite IR-4B resin, and this eluate is evaporated to dryness. The residue is washed with EtOH, then Me2CO, dried and recrystallised from aqueous EtOH (colourless plates) [Baddiley & Jamieson J Chem Soc 4283 1954]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2125 1961, Beilstein 4 IV 3190.]
  • Other biochemical pathways Although mammals cannot synthesize methionine, they can still use it in a variety of biochemical pathways:
    Generation of homocysteine Methionine is converted to S-adenosyl methionine (SAM) by (1) methionine adenosyltransferase.
    SAM serves as a methyl-donor in many (2) methyl transferase reactions, and is converted to S-adenosylhomocysteine (SAH).
    (3) Adenosyl homocysteinase converts SAH to homocysteine.
    There are two fates of homocysteine: it can be used to regenerate methionine, or to form cysteine.
    Regeneration of methionine
    Methionine can be regenerated from homocysteine via methionine synthase in a reaction that requires Vitamin B12 as a cofactor.
    Homocysteine can also be remethylated using glycine betaine (NNN-trimethyl glycine, TMG) to methionine via the enzyme betainehomocysteine methyltransferase (E.C.2.1.1.5, BHMT). BHMT makes up to 1.5% of all the soluble protein of the liver, and recent evidence suggests that it may have a greater influence on methionine and homocysteine homeostasis than methionine synthase.
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59-51-8, DL-メチオニン キーワード:
  • 59-51-8
  • DL-Methioni
  • fructus kochiae extracts
  • 4-Methylmercapto-2-aminobutyricacid
  • alpha-Amino-gamma-methylmercaptobutyric acid
  • Amurex
  • Banthionine
  • butanoicacid,2-amino-4-(methylthio)-,DL-
  • Cynaron
  • DL-2-Amino-3-methylthiobuttersαure
  • Dyprin
  • L-CH3SCH2CH2CH(NH2)COOH
  • Lobamine
  • Meonine
  • Mertionin
  • Methilanin
  • Methilonin
  • Methionine (NF XIV)
  • Methionine dl-form
  • -Methylmercapto-aminobutyricacid
  • Metion
  • L-2-AMINO-4-METHYLMERCAPTOBUTYRIC ACID
  • L-2-AMINO-4-(METHYLTHIO)BUTANOIC ACID
  • acimetion
  • AKOS AUF2097
  • 2-AMINO-4-METHYLMERCAPTOBUTYRIC ACID
  • 2-AMINO-4-METHYLSULFANYL-BUTYRIC ACID
  • 2-AMINO-4(METHYLTHIO)BUTYRIC ACID
  • (S)-(+)-METHIONINE
  • (S)-2-AMINO-4-(METHYLMERCAPTO)BUTYRIC ACID
  • RACEMETHIONINE
  • DL-メチオニン
  • (±)-2-アミノ-4-(メチルチオ)酪酸
  • rac-(R*)-2-アミノ-4-(メチルチオ)ブタン酸
  • rac-(R*)-2-[2-(メチルチオ)エチル]グリシン
  • 2-アミノ-4-メチルチオ酪酸
  • D-メチオニン/L-メチオニン,(1:1)
  • (±)-メチオニン
  • DL-2-アミノ-4-(メチルチオ)酪酸
  • DLメチオニン
  • DL‐メチオニン
  • メチオニン, DL-
  • D L - メチオニン
  • DL-メチオニン, 99%
  • DL-メチオニン (JAN)
  • α-アミノ酸
  • アミノ酸
  • 生化学
  • メチオニン