L-メチオニン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P501：内容物/容器を．．．に廃棄すること。

L-メチオニン 価格

MSDS Information

• L-Methionine

L-メチオニン 化学特性,用途語,生産方法

• 外観

  白色, 結晶～結晶性粉末

• 定義

  本品は、次の化学式で表されるアミノ酸である。

• 溶解性

  水100gに3g (0℃), 5.6g (30℃)溶解。有機溶媒に不溶。酸, アルカリ溶液に可溶。水にやや溶けやすく、エタノールに極めて溶けにくく、ジエチルエーテルにほとんど溶けない。塩酸又は水酸化ナトリウム溶液に溶ける。

• 解説

  L-メチオニン，(S)-2-amino-4-(methylthio)butanoic acid．C5H11NO2S(149.21)．CH3SCH2CH2CH(NH2)COOH．略称MetまたはM．必須アミノ酸の一つで，量的には少ないが分布は広い．発酵法で得られるホモセリンから工業的に合成できる．また，D,L-体はβ-メチルチオアセトアルデヒドからストレッカー法で合成される．生体中でメチル基の供与体として重要であり，ほかのアミノ酸の前駆物質である．六角板状結晶．分解点280～281 ℃．[α]²⁵_D－8.2°(水)．pK1 2.15，pK2 9.06(25 ℃)．水に可溶，エタノール，エーテルに不溶．特異な臭気とわずかに甘みと苦みを有する．栄養剤，医薬として用いる．LD50 29 mmol/kg(ラット，腹腔内)

• 化粧品の成分用途

  ヘアコンディショニング剤、皮膚コンディショニング剤

• 効能

  解毒薬

• 説明

  Colorless or white lustrous plates, or a white crystalline powder. It has a slight, characteristic odor. It is soluble in water, in alkali solutions, and in dilute mineral acids. It is slightly soluble in alcohol and practically insoluble in ether.

• 使用

  L-Methionine is used as an essential amino acid for human development and therapeutically acts as an antidote for acetaminophen poisoning. It serves as a chelating agent for heavy metals, as a flavoring agent and nutritional supplement for foods. It acts as a feed additive, vegetable oil enrichment and as a single cell protein. In addition to this, it is used as a hepatoprotectant and also acts as a lipotropic agent and prevents excess fat buildup in the liver.

• 調製方法

  Numerous methods have been described for manufacture of methionine, including hydrolysis of methionine amide )and 5-(bmethylmercaptoethyl)- hydantoin.

• 製造方法

  The production method of choice for L-methionine is still the enzymatic resolution of racemic N-acetyl-methionine using acylase from Aspergillus oryzae.  The production is carried out in a  continuously operated fixed-bed or enzyme  membrane reactor.

• 定義

  ChEBI: L-methionine is the L-enantiomer of methionine. It has a role as a nutraceutical, a micronutrient, an antidote to paracetamol poisoning, a human metabolite and a mouse metabolite. It is an aspartate family amino acid, a proteinogenic amino acid, a methionine and a L-alpha-amino acid. It is a conjugate base of a L-methioninium. It is a conjugate acid of a L-methioninate. It is an enantiomer of a D-methionine. It is a tautomer of a L-methionine zwitterion.

• 一般的な説明

  Minute hexagonal plates from dilute alcohol.

• 空気と水の反応

  Reacts with water, steam, and/or acids to produce toxic and flammable vapors of hydrogen sulfide . Water soluble . pH of 1% aqueous solution is 5.6-6.0.

• 反応プロフィール

  An organosulfide and amine derivative, carboxylic acid. Look at Reactive Groups 20 (organosulfides), 7 (amines), and 3 (carboxylic acids) may give indications about reactive tendencies. L-Methionine is an amino acid essential in human nutrition.

• 健康ハザード

  ACUTE/CHRONIC HAZARDS: L-Methionine is dangerous when heated to decomposition; it emits dangerous and highly toxic fumes.

• 火災危険

  Flash point data for L-Methionine is not available, but L-Methionine is probably combustible.

• 応用例（製薬）

  Methionine is used in oral pharmaceutical formulations as a flavoring agent.It has been included in parenteral formulations as a pH controlling agent,and it has also been used experimentally as an antioxidant with antibodies.Methionine is also used therapeutically in oral tablets

• 安全性プロファイル

  Mildly toxic by ingestion and intraperitoneal routes. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. An essential sulfur-containing amino acid. When heated to decomposition it emits very toxic fumes of NOx and SOx.

• 安全性

  Methionine is used in oral pharmaceutical formulations. The pure form of methionine is mildly toxic by ingestion and by the IP route.
  LD₅₀ (rat, IP): 4.328 g/k
  LD₅₀ (rat, oral): 36 g/kg

• 概要

  必須アミノ酸の一種．筋肉収縮に必要なエネルギー源としてのホスホクレアチニンの前駆体．生体内でのメチル基転位反応に関与し，生体内でシステインの前駆体としても重要．特異な臭気

• 貯蔵

  Methionine is sensitive to light and should be stored in a cool, dark place.

• 純化方法

  Crystallise L-methionine from aqueous EtOH. Also purify it by dissolving ~0.5g of amino acid in ~10mL of hot H2O, filtering, adjusting the pH to 5.8 with 5N HCl, collecting the solid after addition of ~20mL of EtOH. It is recrystallised by dissolving in H2O and adding EtOH. It sublimes at 197-208o/0.3mm with 99.8% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Milne & Peng J Am Chem Soc 79 647 1957, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2125-2152 1961, Beilstein 4 IV 3189.]

• 不和合性

  Methionine is incompatible with strong oxidizing agents.

• 規制状況(Regulatory Status)

  Included in the FDA Inactive Ingredients Database (oral tablets). Included in parenteral preparations (injection solutions; powders for reconstitution) licensed in the UK.

L-メチオニン 上流と下流の製品情報

L-メチオニン 生産企業

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L-メチオニン スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

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