2,4-ジイソシアン酸トリレン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H315：皮膚刺激

  H317：アレルギー性皮膚反応を起こすおそれ

  H319：強い眼刺激

  H330：吸入すると生命に危険

  H334：吸入するとアレルギー、喘息または、呼吸困難 を起こすおそれ

  H335：呼吸器への刺激のおそれ

  H351：発がんのおそれの疑い

  H412：長期的影響により水生生物に有害

• 注意書き

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

2,4-ジイソシアン酸トリレン 価格

MSDS Information

• 2,4-Diisocyanatotoluene

2,4-ジイソシアン酸トリレン 化学特性,用途語,生産方法

• 外観

  白色/無色粉末～塊～透明液体

• 溶解性

  水, エタノールと激しく反応, エーテルに易溶。エタノール及びアセトンに溶けやすく、水で分解する。

• 解説

  2,4-トリレンジイソシアナート,トリレンジイソシアナート略称2,4-TDI．2,4-ジイソシアナトトルエンともいう．2,4-ジアミノトルエンとホスゲンとの反応で製造される．ポリウレタンの主原料．融点19.5～21.5 ℃，沸点124～126 ℃(2.4 kPa)．d₁₅²⁵"1.22．n_D²⁵"1.5654．水と反応して二酸化炭素を発生し，またアルコール，アミンなどの求核試剤と反応しやすい．ポリアルコールと付加重合させてポリウレタンをつくり，ポリウレタンフォーム，エラストマー，樹脂などとする．皮膚や眼を刺激し，皮膚炎や気管支炎を起こすおそれがある．LD50 4.9～6.7 g/kg(ラット，経口)．

• 用途

  ポリウレタン樹脂、ゴム、塗料、接着剤の原料、繊維処理剤

• 説明

  Toluene diisocyanate (TDI), (OCN)2C6H3CH3, is a water-white to pale-yellow liquid with a sharp, pungent odor. It reacts with water to release carbon dioxide. The specific gravity is 1.22, which is heavier than water. TDI is toxic by inhalation and ingestion, and is a strong irritant to skin and other tissue, particularly the eyes. The TLV is 0.005 ppm in air, and the IDLH is 10 ppm. The target organs are the respiratory system and the skin. The four-digit UN identification number is 2078. The NFPA 704 designation is health 3, flammability 1, and reactivity 3. The white section at the bottom of the diamond has a W with a slash through it, indicating water reactivity. The primary uses of TDI are in the manufacture of polyurethane foams, elastomers, and coatings.

• 化学的特性

  colourless to light yellow liquid

• 物理的性質

  Clear, colorless to light yellow liquid with a pungent, fruity odor. Odor threshold concentration in air is 2.14 ppm_v (Leonardos et al., 1969).

• 使用

  Occupational asthma is the principal cause of work-related respiratory disease in the industrial world. Toluene-2,4-diisocyanate (TDI) is one of the most common respiratory sensitizers leading to occupational asthma.

• 定義

  ChEBI: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.

• 一般的な説明

  2,4-TDI is an environmental contaminant belonging to the class of diisocyanates. It is commercially used as a starting material for varnishes, paints, elastomers, polyurethane foams, wire enamels, etc.

• 空気と水の反応

  Reacts with water with the evolution of carbon dioxide and formation of insoluble polyureas that are relatively nontoxic and inert [Merck 11th ed. 1989)].

• 反応プロフィール

  Tolylene-2,4-diisocyanate is explosive in the form of vapor when exposed to heat, flame or sparks. Undergoes potentially violent polymerization reaction with strong bases or acyl chlorides. Reacts with water to liberate carbon dioxide. Potential explosion if stored in polyethylene containers due to absorption of water through the plastic. Emits very toxic fumes of oxides of nitrogen when heated to decomposition [Lewis, 3rd ed., 1993, p. 1251].

• 危険性

  Toxic by ingestion and inhalation; strong irritant to skin and tissue, especially to eyes. Respiratory sensitization.

• 健康ハザード

  Can cause death. Contact with skin may cause allergic eczema. Substance is very corrosive to eyes. Chronic exposure may cause chronic lung disease. As a vapor TDI is a powerful irritant to the respiratory tract. Chronic loss of respiratory function may occur. Acute asthmatic bronchitis or frank asthma may occur. A splash in the eyes of workmen has caused keratitis and conjunctivitis. Tolylene-2,4-diisocyanate causes inflammation of the skin, also chemical pneumonitis and pulmonary edema.

• 火災危険

  When heated to decomposition Tolylene-2,4-diisocyanate emits very toxic fumes of cyanide and nitrogen oxides. Reacts violently with amines, alcohol, bases and warm water causing fire and explosion hazards. Avoid strong oxidizers, water, acids, bases, amines, etc., cause foam and splatter. Avoid heating. Hazardous polymerization may occur. Concentrated alkaline compound such as sodium hydroxide or tertiary amines may cause run-away polymerization. Slow, not hazardous polymerization may occur above 235F.

• 燃焼性と爆発性

  TDI is a combustible liquid (NFPA rating = 1). Explosive limits in air are 0.9 to 9.5% by volume. Carbon dioxide or dry chemical extinguishers should be used for TDI fires.

• 化学反応性

  Reactivity with Water: A non violent reaction occurs forming carbon dioxide gas and an organic base; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Slow polymerization occurs at temperatures above 113°F. The reaction is not hazardous; Inhibitor of Polymerization: Not pertinent.

• 安全性プロファイル

  Confirmed carcinogen. Poison by ingestion, inhalation, and intravenous routes. Human systemic effects by inhalation: unspecified changes to the eyes and sense of smell, respiratory obstruction, cough, sputum, and other pulmonary and gastrointestinal changes. Mutation data reported. A severe skin and eye irritant. Capable of producing severe dermatitis and bronchial spasm. A common air contaminant. Combustible when exposed to heat or flame. Explosive in the form of vapor when exposed to heat or flame. To fight fire, use dry chemical, CO2. Potentially violent polymerization reaction with bases or acyl chlorides. Reaction with water releases carbon dioxide. Storage in polyethylene containers is hazardous due to absorption of water through the plastic. When heated to decomposition it emits highly toxic fumes of NOx. See also ISOCYANATES.

• 発がん性

  Acute toxicity. Industrial experience has demonstrated that acute exposure to TDI vapors can produce severe irritant effects on mucous membranes, the respiratory tract, and the eyes. An acute attack of an asthma-like syndrome may occur. Exposure to high concentrations may lead to chemical bronchitis with severe bronchospasm, chemical pneumonitis, pulmonary edema, headache, and insomnia.With sufficient exposure, all persons would appear to experience these effects even on their first exposure.
  Chronic and subchronic toxicity. Repeated exposures at lower concentrations of TDI may produce a chronic-like syndrome in many people. Symptoms may include coughing, wheezing, tightness or congestion in the chest, and shortness of breath and appear to be related to hypersensitization. Interstitial pulmonary fibrosis does not occur from moderately elevated exposures to TDI (mean 0.07, peak 0.2 ppm).
  Exposure to TDI may lead to immunological sensitization. Some individuals become sensitized on first exposure; others may develop symptoms after exposure over days, months, or years. Other workers have experienced only minimal or no respiratory symptoms for several months of low level exposure, then suddenly develop acute asthmatic reactions to the same level. The nature of the sensitization process is unknown, and many authors have referred to it as an “allergy;” the respiratory response in sensitized people is referred to as true asthma, comparable to asthma excited by pollens and other exoallergens. Some TDI-sensitized people, however, have no history of prior allergic disease.

• 環境運命予測

  Chemical/Physical. Slowly reacts with water forming carbon dioxide and polyureas (NIOSH, 1997; Windholz et al., 1983).

• 貯蔵

  work with TDI should be conducted in a fume hood to prevent exposure by inhalation, and splash goggles and impermeable gloves should be worn at all times to prevent eye and skin contact.

• 純化方法

  It is purified by fractionation in a vacuum and should be stored in a dry atmosphere. It is soluble in organic solvents but reacts with H2O, alcohols (slowly) and amines, all of which could cause explosive polymerisation. It darkens on exposure to light. It has a sharp pungent odour, is TOXIC and is IRRITATING TO THE EYES. [Siefken Justus Liebigs Ann Chem 562 75, 96, 127 1949, Bayer Angew Chem 59 257 1947.] It is a reagent for covalent crosslinking of proteins [Wold Methods Enzymol 25 623 1972.] [Beilstein 13 IV 243.]

• 不和合性

  Contact with strong oxidizers may cause fires and explosions. Contact with water, acids, bases, and amines can lead to reactions that liberate heat and CO2 and cause violent foaming and spattering. TDI will attack some forms of plastic, rubber, and coatings.

• 廃棄物の処理

  Excess TDI and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.

• 予防処置

  Occupational workers should be careful during use and waste disposal of toluene diisocyanate. Use and storage of toluene diisocyanate requires precautions. It polymerizes under the infl uence of bases, tertiary amines, and acyl chlorides with fi re or explosion hazard. On combustion, it forms toxic vapors and gases, including nitrogen oxides and isocyanates. Toluene diisocyanate reacts readily with water, acids, and alcohols, and causes explosion hazard. The development of any unusual signs or symptoms, such as headache, increased pain or a discharge from the eyes, increased redness or pain or a pus-like discharge in the area of a skin burn within 24 h after exposure to toluene diisocyanate, requires immediate medical support to the exposed worker.

2,4-ジイソシアン酸トリレン 上流と下流の製品情報

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2,4-ジイソシアン酸トリレン スペクトルデータ(¹³CNMR、IR1、MS、Raman)

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