フェナセチン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H302：飲み込むと有害

  H350：発がんのおそれ

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

フェナセチン 価格

MSDS Information

• 4-Acetophenetidine

フェナセチン 化学特性,用途語,生産方法

• 外観

  白色, 結晶～結晶性粉末

• 溶解性

  水に不溶。エタノールに可溶。エーテルに微溶。エタノールに可溶、エーテルに難溶。熱水に可溶(1g/80ml溶媒)、水に極めて難溶。エタノールにやや溶けやすく、ジエチルエーテルに溶けにくく、水に極めて溶けにくい。

• 解説

  フェナセチン，p-ニトロフェノールのNa塩をヨウ化エチルを用いてエチルエーテルとする．ついでニトロ基を還元しアミンとしてからアセチル化すると得られる．白色の結晶または結晶性の粉末．融点134～136 ℃．エタノール，クロロホルムに可溶，エーテル，水に難溶．下熱，鎮痛剤として用いられる．チアノーゼ，呼吸困難，頻脈，冷汗，体温降下などを伴う虚脱症状など，アセトアニリドと同様な副作用を起こす．LD50 1.65 g/kg(ラット，経口)．

• 用途

  医薬(解熱剤,鎮痛剤)

• 用途

  薬理研究用、有機合成原料。

• 用途

  アニリン系化合物です。体内 でアセトアミノフェンに代謝されて作用を示 します。

• 用途

  アニリン系化合物です。体内 でアセトアミノフェンに代謝されて作用を示 します。

• 用途

  アスピリンと同様に視床下部の体温調節中枢に作用して熱放散を促進させ解熱する。アスピリンまたはアミノピリンとカフェインとによる配合剤が風邪薬として頻(ひん)用されていたが，血液障害，腎毒性，発癌作用の疑いのためほとんど使われなくなっている。

• 効能

  解熱薬

• 説明

  Phenacetin, a painkiller, was the world’s first synthetic pharmaceutical drug. It was one of the first painkillers that was not derived from opium while at the same time being absent of antiinflammatory qualities. Phenacetinwas developed in 1878 by an American chemist, Harmon Northrop Morse. It was introduced into the pharmaceutical market in 1887. However, it was withdrawn in 1983 in the United States due to unacceptable levels of interstitial nephritis in patients and potential risks of tumorigenicity. Like in the United States, most Western countries did not ban phenacetin from marketing until 1983. Phenacetin is a component of APC (aspirin-phenacetin-caffeine).

• 化学的特性

  Acetophenetidin is a fine, white, crystalline powder or solid. Odorless with a slightly bitter taste

• 使用

  Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.

• 定義

  ChEBI: Phenacetin is a member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group. It has a role as a non-narcotic analgesic, a peripheral nervous system drug and a cyclooxygenase 3 inhibitor. It is a member of acetamides and an aromatic ether. It is functionally related to a N-phenylacetamide, a 4-ethoxyaniline and a paracetamol.

• 世界保健機関（WHO）

  Phenacetin, an aniline derivative, was introduced into medicine as an antipyretic over a century ago. It subsequently gained recognition as an analgesic and was available in many proprietary analgesic preparations. However, in the 1940s its habitual use was first implicated as the cause of methaemoglobinaemia and chronic haemolysis. Since 1950 there have been many reports published indicating that abusive use is associated with cumulative renal damage. Evidence also exists to suggest that it may have a carcinogenic potential. The drug has been withdrawn in many countries but may remain available in others. (Reference: (WHODI) WHO Drug Information, 1, 5, 1980)

• 一般的な説明

  Phenacetin is an odorless fine white crystalline solid with a lightly bitter taste. Used as an analgesic medicine.

• 空気と水の反応

  Insoluble in water.

• 反応プロフィール

  Phenacetin react with oxidizing agents, iodine and nitrating agents.

• 火災危険

  Flash point data for Phenacetin are not available but Phenacetin is probably combustible.

• 安全性プロファイル

  Confirmed carcinogen producing tumors of the lildney and bladder. A human poison by an unspecified route. Poison by intravenous and possibly other routes. Moderately toxic by several routes. Human systemic effects by ingestion: cyanosis, liver damage, and methemoglobinemiacarboxyhemo-globinemia. Experimental teratogenic data. Other experimental reproductive effects. Mutation data reported. Chronic effects consist of weight loss, insomnia, shortness of breath, weakness, and often aplastic anemia. When heated to decomposition it emits toxic fumes of NOx,.

• 職業ばく露

  Phenacetin is used as an analgesic and antipyretic drug. It is used alone or in combination with aspirin and caffeine for mild to moderate muscle pain relief. Phenacetin has also been used as a stabilizer for hydrogen peroxide in hair bleaching preparations. A laboratory reagent. In veterinary medicine; it is used as an analgesic and antipyretic.

• 発がん性

  Phenacetin is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

• 環境運命予測

  Phenacetin occurs at room temperature as white, odorless monoclinic prisms. It is soluble in water, alcohol, glycerol, and acetone and is slightly soluble in benzene. It is unstable to oxidizing agents, iodine, and nitrating agents. Phenacetin has a melting point of 134–135 °C; log Kow of 1.58; water solubility of 30 mg l^-1 at 25 °C; and vapor pressure of 0.00316mmHg at 25 °C.
  Phenacetin’s former use and production as an analgesic may have allowed release into the environment through various waste streams. Phenacetin exists both as vapor and as particulate if released to air. The vapor phase is expected to be readily degraded by reaction with photochemically produced hydroxyl radicals with a half-life reaction of 22 h. The particular phase, however, is removed by wet and dry deposition reactions. Phenacetin can enter the environment through leaching into groundwater when released into the soil with moderate mobility. When released into the water, it does not adsorb to suspended solids and sediment, but is expected to be inert to reaction with naturally occurring oxidants found in water with a half-life of more than 30 days. Phenacetin has an estimated bioconcentration factor of less than 100, and is not expected to significantly bioaccumulate. Volatilization is insignificant.

• 輸送方法

  UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

• 純化方法

  Crystallise it from H2O or EtOH, and its solubility in H2O is 0.08% (at ~10o) and 1.2% (at ~100o), and in EtOH it is 6.7% (at ~10o) and 36% (at ~100o). Alternatively it can be purified by solution in cold dilute alkali and re-precipitating by addition of acid to neutralisation point. Dry it in air. [Beilstein 13 H 461, 13 IV 1092.]

• 不和合性

  Oxidizing agents, iodine and nitrating agents.

• 廃棄物の処理

  It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible, return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Permanganate oxidation, microwave plasma treatment, alkaline hydrolysis or incineration.

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フェナセチン スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

62-44-2, フェナセチン キーワード