クロルプロマジン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

クロルプロマジン 価格

クロルプロマジン 化学特性,用途語,生産方法

• 解説

  2-chloro-10-[(3-dimethylamino)propyl]phenothiazine．C17H19ClN2S(318.87)．2-クロロフェノチアジンにナトリウムアミドの存在下で3-(ジメチルアミノ)プロピルクロリドを作用させると得られる．"アミン臭のある油状液体．沸点200～205 ℃(0.1 kPa)．精神分裂症に用いられるトランキライザー．少量で鎮静作用を，大量で睡眠を起こさせる．塩酸塩は白色の結晶．融点194～196 ℃．LD50 405 mg/kg(マウス，経口)[CAS 50-53-3][CAS 14923-91-2:塩酸塩]
  森北出版「化学辞典（第2版）

• 用途

  抗精神病薬統合失調症，非定型精神病，中毒性精神病，器質性精神病などに用いられ，躁うつ病にも補助的に用いられる 。

• 効能

  統合失調症治療薬, 制吐薬

• 説明

  This phenothiazine with sedative properties is used in human medicines and has induced contact dermatitis in nurses or in those working in the pharmaceutical industry. It is also used in veterinary medicine to avoid mortality of pigs during transportation. It is a sensitizer and a photosensitizer.

• 化学的特性

  Oily liquid; amine odor.

• 使用

  In psychiatric practice, chlorpromazine is used in various conditions of psychomotor excitement in patients with schizophrenia, chronic paranoid and also manic-depressive conditions, neurosis, alcohol psychosis and neurosis accompanied by excitement, fear, stress, and insomnia. In comparison with other neuroleptics, chlorpromazine is unique in that it has an expressed sedative effect. It is sometimes used in anesthesiological practice for potentiating narcosis. It also has moderate anticonvulsant action.

• 定義

  ChEBI: A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.

• 危険性

  Toxic by ingestion.

• 接触アレルゲン

  This phenothiazine with sedative properties is used in human medicine and induced contact dermatitis in nurses or those working in the pharmaceutical industry. It is also used in veterinary medicine to avoid mortality of pigs during transportation. It is a sensitizer and a photosensitizer.

• 環境運命予測

  Acute and chronic toxicity due to chlorpromazine generally manifests as an extension of normal pharmacological activity. The precise mechanism of action of chlorpromazine, and other phenothiazines, is unknown; however, it is thought to primarily involve antagonism of dopaminergic (D2) neurotransmission at synaptic sites and blockade of postsynaptic dopamine receptor sites at the subcortical levels of the reticular formation, limbic system, and hypothalamus. This activity contributes to chlorpromazine’s extrapyramidal reactions. Chlorpromazine also has strong central and peripheral activity directed against adrenergic receptors and weak activity against serotonergic, histaminic (H1), and muscarinic receptors. Chlorpromazine has slight ganglionic blocking action. Chlorpromazine is known to depress vasomotor reflexes medicated by the hypothalamus and/or brain stem; inhibit release of growth hormone; antagonize secretion of prolactin release-inhibiting hormone; and reduce secretion of corticotropin-regulatory hormone.
  Chlorpromazine also has direct effects on cardiac myocytes; it can induce early after-depolarizations, block depolarizing sodium channels, and cause significant prolongation of the QTc interval.
  Chlorpromazine may be irritating to eyes, mucous membranes, and skin. Contact and inhalation should be avoided.

• 代謝経路

  The in vivo photodegradation of chlorpromazine in rat skin exposed to UV-A results in the formation of promazine and 2-hydroxypromazine in irradiated rats, but not in the skin of rats kept in the dark. Chlorpromazine sulfoxide is a major metabolite of chlorpromazine, found in smaller quantity in the skin of irradiated rats compared with those kept in the dark. Chlorpromazine sulfoxide is not a photoproduct of chlorpromazine under the experimental conditions.

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50-53-3, クロルプロマジン キーワード