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1-(1-ナフチル)-2-チオ尿素

1-(1-ナフチル)-2-チオ尿素 化学構造式
86-88-4
  • CAS番号.86-88-4
  • 化学名:1-(1-ナフチル)-2-チオ尿素
  • 别名:1-(1-ナフチル)-2-チオ尿素;クリシド;ラットラック;バンツ;1-(1-ナフチル)チオ尿素;アンツラット;N-(1-ナフチル)チオ尿素;1-ナフチルチオ尿素;N-(1-ナフチル)-2-チオ尿素;N(1ナフチル)2チオ尿素;α-ナフチルチオ尿素;1‐(1‐ナフチル)‐2‐チオ尿素;アンツー標準品;α-ナフチルチオ尿素, 97%
  • 英語化学名:1-(1-NAPHTHYL)-2-THIOUREA
  • 英語别名:ANTU;AUTU;Bantu;Dirax;Alrato;u-5227;Kripid;Krysid;Rat-Tu;U 5227
  • CBNumber:CB5308200
  • Molecular Formula:C11H10N2S
  • Formula Weight:202.28
  • MOL File:86-88-4.mol
1-(1-ナフチル)-2-チオ尿素 物理性質
  • 融点  :193 °C
  • 沸点  :377.6±25.0 °C(Predicted)
  • 比重(密度)  :1.333
  • 屈折率  :1.5500 (estimate)
  • 貯蔵温度  :Poison room
  • 溶解性 :4.3 and 86 g/L in acetone and triethylene glycol, respectively (Windholz et al., 1983)
  • 酸解離定数(Pka) :13.12±0.70(Predicted)
  • 外見  :Crystals or Crystalline Powder
  • 色 :Grayish to beige-brown
  • 臭い (Odor) :bitter taste
  • 水溶解度  :600 mg/L at 20 °C (quoted, Windholz et al., 1983)
  • Merck  :14,722
  • BRN  :778118
  • 暴露限界値 :NIOSH REL: TWA 0.3 mg/m3, IDLH 100 mg/m3; OSHA PEL: TWA 0.3 mg/m3
  • CAS データベース :86-88-4(CAS DataBase Reference)
  • IARC :3 (Vol. 30, Sup 7) 1987
  • EPAの化学物質情報 :.alpha.-Naphthylthiourea (86-88-4)
安全性情報
  • 主な危険性  :T+
  • Rフレーズ  :28-40
  • Sフレーズ  :28-36/37-45-25-23
  • RIDADR  :1651
  • WGK Germany  :2
  • RTECS 番号 :YT9275000
  • TSCA  :Yes
  • 国連危険物分類  :6.1
  • 容器等級  :I
  • HSコード  :29309090
  • 有毒物質データの :86-88-4(Hazardous Substances Data)
  • 毒性 :Acute oral LD50 for Norwegian rats 6–8 mg/kg (Hartley and Kidd, 1987).
危険有害性情報のコード(GHS)
  • 絵表示(GHS)
  • 注意喚起語Danger
  • 危険有害性情報
  • H300:飲み込むと生命に危険
  • H351:発がんのおそれの疑い
  • 注意書き
  • P301+P330+P331:飲み込んだ場合:口をすすぐこと。無理に吐かせ ないこと。
  • P309:暴露したとき、または気分が悪い時:
  • P310:ただちに医師に連絡すること。
1-(1-ナフチル)-2-チオ尿素 価格 もっと(8)
  • メーカー: 富士フイルム和光純薬株式会社(wako)
  • 製品番号: W01AFAA19024
  • 製品説明 : α-ナフチルチオ尿素, 97%
  • 純度: alpha-Naphthylthiourea, 97%
  • 包装: 50g
  • 価格: ¥42880
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 富士フイルム和光純薬株式会社(wako)
  • 製品番号: W01AFAA19024
  • 製品説明 : α-ナフチルチオ尿素, 97%
  • 純度: alpha-Naphthylthiourea, 97%
  • 包装: 250g
  • 価格: ¥171520
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 東京化成工業
  • 製品番号: N0071
  • 製品説明 : 1-(1-ナフチル)-2-チオ尿素
  • 純度: 1-(1-Naphthyl)-2-thiourea >98.0%(HPLC)(N)
  • 包装: 5g
  • 価格: ¥3500
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 東京化成工業
  • 製品番号: N0071
  • 製品説明 : 1-(1-ナフチル)-2-チオ尿素
  • 純度: 1-(1-Naphthyl)-2-thiourea >98.0%(HPLC)(N)
  • 包装: 25g
  • 価格: ¥10200
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 関東化学株式会社(KANTO)
  • 製品番号: 41543-1A
  • 製品説明 : 1‐(1‐ナフチル)‐2‐チオ尿素
  • 純度: 1‐(1‐Naphthyl)‐2‐thiourea97%
  • 包装: 25g
  • 価格: ¥11300
  • 更新時間: 2021/03/23
  • 購入: 購入

1-(1-NAPHTHYL)-2-THIOUREA 化学特性,用途語,生産方法

  • 外観 白色~うすい黄色粉末~結晶
  • 用途 農薬(殺ソ剤)
  • 説明 a-Naphthylthiourea (ANTU; also called DIRAX) is toxic by inhalation, ingestion, or skin contact. Due to its very narrow spectrum of activity, production was discontinued a long time ago. Exposure to ANTU causes pulmonary edema; therefore, it is often used as an experimental pneumotoxin. ANTU is a graycolored, prism-shaped, odorless powder with a bitter taste. It has a molecular weight of 202.28 and melting point of 200 ℃ and does not ignite readily. However, on interaction with potential oxidizing agents, it may cause fire and explosions, which can lead to hazardous decomposition products such as sulfur dioxide, nitrogen dioxide, and carbon monoxide. The structure of ANTU contains the naphthalene chromophore, which absorbs UV light at ~311 nm. This suggests that ANTU can undergo photolysis.
  • 化学的特性 greyish to beige-brown crystals or cryst. powder
  • 化学的特性 Alpha-naphthylthiourea (α-naphthalene thiourea) is a pure white or beige-brown solid/ blue-gray powder. It is hard to dissolve in water, acid, and general organic solvents, but dissolves in boiling ethanol and alkaline solution. On decomposition, ANTU releases carbon monoxide, toxic and irritating fumes and gases, and carbon dioxide. It is a rodenticide and a poison bait to lure rodents.
  • 化学的特性 ANTU is a noncombustible, white crystalline solid or gray powder. Odorless.
  • 物理的性質 Colorless crystals when pure. Technical product is grayish-blue. Odorless solid. Bitter taste.
  • 使用 Rodenticide
  • 使用 ANTU an organosulfur is a derivative of thiourea. It is a singledose rodenticide that is specifically used against Norway rats as a bait. However, it is futile against all other species of rodents. Because of its tendency to cause resistance and specificity only toward Norway rodents, this poison rapidly lost popularity and is no longer manufactured in the United States.
  • 使用 Rodenticide. Specific control for the adult Norway rat; less toxic to other rat species.
  • 一般的な説明 White crystal or powder; technical product is gray powder. Has no odor but a bitter taste. Used primarily as a rodenticide for control of adult Norway rats. Not produced commercially in the U.S.
  • 空気と水の反応 Slightly soluble in water.
  • 反応プロフィール 1-(1-NAPHTHYL)-2-THIOUREA is incompatible with the following: Strong oxidizers, silver nitrate .
  • 危険性 Toxic by ingestion
  • 健康ハザード Moderately toxic: probable oral lethal dose (human) 0.5-5 gm/kg, or between 1 ounce and 1 pint (or l lb.) for 150 lb. person. Chronic sublethal exposure may cause antithyroid activity. Can produce hyperglycemia of three times normal in three hours. People with chronic respiratory disease or liver disease may be especially at risk.
  • 健康ハザード α-Naphthalene thiourea, a rodenticide, is very toxic and is fatal if swallowed. Exposures to ANTU cause poisoning with symptoms that include, but are not limited to, headache, weakness, dizziness, shortness of breath, cyanosis, blood abnormalities, methemoglobinemia, irritation of the digestive tract, liver and kidney damage, cardiac and CNS disturbances, convulsions, tachycardia, dyspnea, vertigo, tinnitus, weakness, disorientation, lethargy, drowsiness, and fi nally coma and death. The target organs include the blood, kidneys, CNS, liver, lungs, cardiovascular system, and blood-forming organs.
  • 火災危険 Emits sulfur dioxide, oxides of nitrogen, and carbon monoxide fumes upon decomposition. 1-(1-NAPHTHYL)-2-THIOUREA reacts with silver nitrate and strong oxidizers. Avoid decomposing heat.
  • 安全性プロファイル Poison by ingestion and intraperitoneal routes. Moderately toxic to humans by an unspecified route. Questionable carcinogen with experimental tumorigenic data. Mutagenic data. A rodenticide used extensively. Death is caused by pulmonary edema. Chronic toxicity has been known to cause dermatitis and a decrease in the white blood cells. When heated to decomposition it emits toxic fumes of NOx and SOx.
  • 職業ばく露 ANTU or its formulations are used as a rodenticide.
  • Carcinogenicity ANTU was not carcinogenic in rodent feeding studies.4 Cases of bladder tumors among rat catchers exposed to ANTU have been attributed to b-naphthylamine, a manufacturing impurity of ANTU. In bacterial assays ANTU induced mutations.
  • 環境運命予測 Chemical/Physical. The hydrolysis rate constant for ANTU at pH 7 and 25°C was determined to be 8 × 10–5/hour, resulting in a half-life of 361 days (Ellington et al., 1988)
    Emits very toxic fumes of nitrogen and sulfur oxides when heated to decomposition (Lewis, 1990)
  • 貯蔵 α-Naphthalene thiourea should be kept stored in a tightly closed container in a locked poison room, in a cool, dry, well-ventilated area away from incompatible substances.
  • 輸送方法 UN1651 Naphthylthiourea, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
  • 純化方法 Crystallise ANTU from EtOH. [Beilstein 12 III 2941, 12 IV 3086.]
  • Toxicity evaluation ANTU toxicity in the rat is thought to depend on metabolic activation via the hepatic and lung microsomal enzymes. Two important metabolites are formed: ANU and atomic sulfur. ANTU pulmonary toxicity may result, in part, from covalent binding of sulfur or a metabolite containing carbonyl carbon of ANTU to macromolecules of liver and lung microsomes. The covalent binding of atomic sulfur released in the cytochrome P450 monooxygenase-catalyzed metabolism of thiono-sulfur compounds is responsible for monooxygenase activity being inhibited. Damage to liver and possibly lung edema and neoplasia result from the covalent binding of the electrophilic S-oxides, S-dioxides or carbene derivatives of these S-oxides and S-dioxides to tissue macromolecules.
    However, it is not known if these metabolites are seen in humans. ANTU is believed to act on certain enzyme systems involving the sulfhydryl group similar to other sulfhydryl inhibitors, such as alloxan, iodoacetamide, and oxophenarsine, which cause pulmonary edema. Hence the mechanism of action of causing pulmonary edema from the toxic effects of these sulfhydryl inhibitors and ANTU is assumed to be similar. Additionally, ANTU-induced lung damage has been linked to the formation of oxygen free radicals produced via the cyclooxygenase pathway. Following exposure to ANTU, there are a number of biochemical events, such as alteration in carbohydrate metabolism, adrenal stimulation, and interaction of the chemical with sulfhydryl groups, but none of these appear to bear any relationship to the observed signs of toxicity.
  • 不和合性 Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, silver nitrate.
  • 廃棄物の処理 Incinerate in a furnace equipped with an alkaline scrubber. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
  • 予防処置 Workers should use/handle α-naphthalene thiourea with adequate ventilation. During use, dust generation and accumulation should be minimum, and avoid contact with the eyes, skin, and clothing.
1-(1-ナフチル)-2-チオ尿素 上流と下流の製品情報
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86-88-4, 1-(1-ナフチル)-2-チオ尿素 キーワード:
  • 86-88-4
  • 1-(1-naphthyl)-2-thio-ure
  • 1-(1-naphthyl)thiourea
  • 1-Naftil-tiourea
  • 1-Naftylthioureum
  • 1-naphthalenyl-thioure
  • 1-Naphthalenylthiourea
  • 1-Naphthyl-thioharnstoff
  • 1-Naphthyl-thiouree
  • 1-naphthyl-thiouree(french)
  • alpha-Naftylthiomocovina
  • alpha-Naphthalthioharnstoff
  • alpha-Naphthothiourea
  • alpha-Naphthylthiocarbamide
  • Alphanaphtyl thiouree
  • alphanaphtylthiouree
  • Alrato
  • u-5227
  • Urea, 1-(1-naphthyl)-2-thio-
  • USAF ek-p-5976
  • usafek-p-5976
  • RATTRACK(R)
  • α-Naphthylthiourea
  • NAPHTHALEN-1-YL-THIOUREA
  • 1-(1-phthyl)-2-thiourea
  • LABOTEST-BB LT02090877
  • 1-(1-NAPHTHYL)-2-THIOUREA
  • 1-(1-NAPHYTHYL)-2-THIOUREA
  • 1-NAPHTHYL-2-THIOUREA
  • 1-NAPHTHYLTHIOUREA
  • ALPHA-NAPHTHYLTHIOUREA
  • 1-(1-ナフチル)-2-チオ尿素
  • クリシド
  • ラットラック
  • バンツ
  • 1-(1-ナフチル)チオ尿素
  • アンツラット
  • N-(1-ナフチル)チオ尿素
  • 1-ナフチルチオ尿素
  • N-(1-ナフチル)-2-チオ尿素
  • N(1ナフチル)2チオ尿素
  • α-ナフチルチオ尿素
  • 1‐(1‐ナフチル)‐2‐チオ尿素
  • アンツー標準品
  • α-ナフチルチオ尿素, 97%