モダフィニル

化学名:モダフィニル

CAS番号.68693-11-8

英語名:Modafinil

CBNumberCB5223833

MFC15H15NO2S

MW273.35

MOL File68693-11-8.mol

别名

(ベンズヒドリルスルフィニル)アセトアミド

モディオダール

2-[(ジフェニルメチル)スルフィニル]アセトアミド

モダフィニル物理性質

融点	164-166°C
沸点	559.1±50.0 °C(Predicted)
比重(密度)	1.283±0.06 g/cm3(Predicted)
闪点	2℃
貯蔵温度	Store at +4°C
溶解性	DMSO: 18 mg/mL、可溶
外見	白い固体
酸解離定数(Pka)	14.88±0.40(Predicted)
色	白い
BCS Class	4
主な用途	法医学と毒物学
InChI	1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
InChIKey	YFGHCGITMMYXAQ-UHFFFAOYSA-N
SMILES	NC(=O)CS(=O)C(c1ccccc1)c2ccccc2
CAS データベース	68693-11-8(CAS DataBase Reference)

安全性情報

主な危険性	T+,Xn,F
Rフレーズ	26/27/28-36-20/21/22-11
Sフレーズ	24/25-45-36/37/39-22-36/37-16
RIDADR	UN 1648 3 / PGII
WGK Germany	3
HSコード	29309090
ストレージクラス	3 - Flammable liquids
Hazard Classifications	Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 2
有毒物質データの	68693-11-8(Hazardous Substances Data)

危険有害性情報のコード(GHS)

MSDS Information

モダフィニル化学特性,用途語,生産方法

用途
第1種向精神薬睡眠覚醒障害治療
効能
中枢神経刺激薬
商品名
モディオダール (アルフレッサファーマ); モディオダール (アルフレッサファーマ)
説明
Modafinil, a centrally active α₁-adrenergic agonist, was marketed in France as a psychostimulant for the treatment of narcolepsy and idiopathic hypersomnia including Gelineau's syndrome. In monkeys, modafinil was found to induce potent behavioral stimulation and awakening without stereotyped behavior. In narcoleptic patients, modafinil reduces the daily number of sleep attacks significantly and markedly improves performance. The mechanism of action for its locomotor effects was reported to be due to the stimulation of the central α₁-adrenergic system, opposite to amphetamine and methylphenidate, which act mainly by dopaminergic mechanisms. Modafinil has been reported to exhibit minimal peripheral side effects at therapeutic doses and appears to have low abuse potential. The use of modafinil in the treatment of cerebral infarction and ischemia has been claimed.
化学的特性
Crystalline Solid
使用
Modafinil is an α-1-adrenergic agonist. Modafinil is a CNS stimulant; psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease.
一般的な説明
Modafinil (Provigil) has overall wakefulness-promotingproperties similar to those of central sympathomimetics. It isconsidered an atypical α1-norepinephrine (NE) receptorstimulant and is used to treat daytime sleepiness in narcolepsypatients. Adverse reactions at therapeutic doses arereportedly not severe and may include nervousness, anxiety,and insomnia. Modafinil is used by oral administration.
生物活性
Psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Promotes vigilence and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.

モダフィニル上流と下流の製品情報

68693-11-8, モダフィニルキーワード

Send Inquriy

モダフィニル

危険有害性情報のコード(GHS)

MSDS Information

モダフィニル 化学特性,用途語,生産方法

モダフィニル 上流と下流の製品情報

68693-11-8, モダフィニル キーワード

モダフィニル化学特性,用途語,生産方法

モダフィニル上流と下流の製品情報

68693-11-8, モダフィニルキーワード