塩酸ナイトロジェンマスタード-N-オキシド

塩酸ナイトロジェンマスタード-N-オキシド 化学特性,用途語,生産方法

• 効能

  抗悪性腫瘍薬, アルキル化剤

• 安全性プロファイル

  Suspected carcinogen with experimental tumorigenic data. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Mutation data reported. An antineoplastic agent. When heated to decomposition it emits toxic fumes of Cland NOx.

• 発がん性

  Nitrogen mustard N-oxide is reportedly carcinogenic in mice and rats. Following subcutaneous administration in mice, it produced lung tumors, thymic lymphomas, and Harderian gland adenomas. Mice given two weekly injections either intravenously, intraperitoneally, or subcutaneously for 15 weeks showed an increase in lymphomas, fibrosarcomas, pulmonary adenomas, and liver hemangiomas. In rats given the material intravenously, it mainly produced lymphoreticular tumors and sarcomas. The preceding data were evaluated by the IARC and considered “sufficient evidence of carcinogenicity in animals.” Based on this evaluation and its mutagenic potential, the IARC classified nitrogen mustard N-oxide in Group 2B (possibly carcinogenic to humans).

塩酸ナイトロジェンマスタード-N-オキシド 生産企業

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