臭化アセチル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H227：引火性液体

  H290：金属腐食のおそれ

  H314：重篤な皮膚の薬傷?眼の損傷

  H335：呼吸器への刺激のおそれ

  H412：長期的影響により水生生物に有害

• 注意書き

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P234：他の容器に移し替えないこと。

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P271：屋外または換気の良い場所でのみ使用すること。

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P330+P331：飲み込んだ場合：口をすすぐこと。無理に吐かせ ないこと。

  P303+P361+P353：皮膚（または髪）に付着した場合：直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。

  P363：汚染された衣類を再使用す場合には洗濯をすること。

  P370+P378：火災の場合：消火に．．．を使用すること。

  P390：物的被害を防止するためにも流出したものを吸収 すること。

  P403+P233：換気の良い場所で保管すること。容器を密閉 しておくこと。

  P403+P235：換気の良い場所で保管すること。涼しいところに 置くこと。

  P405：施錠して保管すること。

  P406：耐腐食性/耐腐食性内張りのある．．．容器に 保管すること。

  P501：内容物/容器を．．．に廃棄すること。

臭化アセチル 価格

MSDS Information

• Acetyl bromide

臭化アセチル 化学特性,用途語,生産方法

• 外観

  無色～黄褐色, 澄明の液体

• 溶解性

  水, アルコールに激しく分解。エーテル, クロロホルムに混和。水又はエタノールと激しく反応して分解する。

• 解説

  臭化アセチル，刺激臭のある発煙性無色液体。酢酸または無水酢酸に三臭化リンを作用させて合成する。エーテル、ベンゼンには溶けるが、水とは激しく反応して酢酸と臭化水素になる。アルコールとも反応し酢酸エステルとなる。カルボニル基炭素原子上での反応により臭素原子が他の原子団と交換されやすいため、有機化合物にアセチル基CH3CO-を導入するアセチル化剤となる。塩化アセチルより反応活性はすこし低い。催涙性があり、皮膚、目、粘膜を刺激する。
  

  小学館　日本大百科全書(ニッポニカ) ）
  

• 用途

  水酸基の選択的アセチル化剤

• 製造

  臭化アセチル，酢酸CH3COOHのヒドロキシ基-OHを臭素原子に置換した化合物。正しくは臭化エタノイルというが、一般的に臭化アセチルといわれている。

• 説明

  Acetyl bromide is a colourless fuming liquid with pungent odour, is combustible, and turns yellow on exposure to air. It is used as an acetylating agent in the synthesis of fine chemicals, agrochemicals, and pharmaceuticals. It is also used as an intermediate for dyes. Acetylation, a case of acylation, is an organic synthesis process whereby the acetyl group is incorporated into a molecule by substitution for protecting –OH groups.

• 化学的特性

  Acetyl bromide is a colorless, fuming liquid that turns yellow on contact with air. It has a sharp, unpleasant odor. Soluble in benzene, ether and methyl chloride. Reacts violently with water or alcohol.

• 使用

  Acetyl Bromide is used as an acetylating agent in the synthesis of fine chemicals, agrochemicals and pharmaceuticals. It is also used as an intermediate for dyes. Further, it reacts with alcohols and amines to produce acetate esters and acetamides. In addition to this, it is involved in the synthetic process of the anti-HIV agent.

• 主な応用

  Acetyl bromide can be used:
  In the quantification of lignin in cell wall residues of Arabidopsis.
  In the total synthesis of cinchona alkaloids named quinidine and quinine.
  To prepare 9,10-diarylanthracenes and triarylmethanes by reacting with arenes and various aromatic aldehydes using ZnBr2/SiO2.
  To prepare glycosyl bromides from free sugars or their peracetates.

• 製造方法

  The preparation of acetyl bromide from acetic acid and bromine in the presence of red and yellow phosphorus.
  Reaction: Acetic anhydride was brominated with bromine at 80°C, and then the bromine was added between 95°C and 125°C. About 2.5h. After the addition was completed, reflux was continued for 3h and left overnight. Refined by fractional distillation.
  Acetyl bromide may also be prepared by reaction between phosphorus tribromide and acetic acid:
  3CH3COOH + PBr3 → 3 CH3COBr + H3PO3

• 一般的な説明

  A colorless fuming liquid with a pungent odor. Vapors irritate eyes and mucous membranes. Corrosive to metals and tissue. Density 13.9 lb / gal.

• 反応プロフィール

  Acetyl bromide decomposes violently upon contact with water, steam, methanol or ethanol to form hydrogen bromide gas and acetic acid. Reacts vigorously with bases, both organic and inorganic. Incompatible with oxidizing agents and alcohols. Produces highly toxic fumes of bromine and carbonyl bromide when heated to decomposition [Sax, 9th ed., 1996, p. 34]. Vapor forms an explosive mixture with air [Kirk-Othmer, 3rd ed., Vol. 1, 1978, p. 162]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

• 健康ハザード

  Exposures to acetyl bromide cause abdominal pain, sore throat, cough, burning sensation, shortness of breath, and respiratory distress. Contact with the skin causes pain, redness, blisters, dermatitis, and skin burn, severe deep burns, loss of vision, shock or collapse. The occupational worker may show delayed symptoms and lung edema. The vapor is corrosive to the eyes, the skin, and the respiratory tract. The irritation caused by acetyl bromide may lead to chemical pneumonitis and pulmonary edema, and may cause burns to the respiratory tract. The target organs include the eyes, skin, and the mucous membranes.

• 化学反応性

  Reactivity with Water: Reacts violently, forming corrosive and toxic fumes of hydrogen bromide; Reactivity with Common Materials: Attacks and corrodes wood and most metals in the presence of moisture. Flammable hydrogen gas may collect in enclosed spaces; Stability During Transport: Stable if protected from moisture; Neutralizing Agents for Acids and Caustics: Flood with water, rinse with dilute sodium bicarbonate or soda ash solution; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

• 安全性プロファイル

  Poison by ingestion, inhalation, skin contact, and intraperitoneal routes. See also HYDROBROMIC ACID and ACETIC ACID. Violent reaction on contact with water, steam, methanol, or ethanol produces toxic and reactive HBr. When heated to decomposition it emits highly corrosive and toxic fumes of carbonyl bromide and bromine. To fight fire, use dry chemical, CO2

• 職業ばく露

  Acetyl bromide is used as an acetylating agent in the organic synthesis of other chemicals, pesticides, perfume, pharmaceuticals, and it is also used as a dye intermediate.

• 貯蔵

  Acetyl bromide should be stored in a tightly sealed container, in a cool, dry, well-ventilated area, away from water and incompatible substances.

• 輸送方法

  UN1716 Acetyl bromide, Hazard class: 8; Labels: 8-Corrosive material

• 純化方法

  Boil acetyl bromide with PBr3/Ac2O for 1hour, then distil the latter off and redistil it. Store it dry. [Burton & Degering J Am Chem Soc 62 227 1940, Beilstein 2 IV 398.] LACHRYMATORY.

• 不和合性

  Acetyl bromide Vapor may form explosive mixture with air. Instability increases as temperature rises, Contact with moisture, water, steam, alcohols cause a violent reaction releasing corrosive carbonyl bromide, hydrogen bromide, and bromine gases. Incompatible with organic solvents, ethers, oxidizers, and strong bases. Corrodes or attacks most metals and wood in the presence of moisture. Contact with combustibles may cause ignition

• 廃棄物の処理

  Dispose of contents and container to an approved waste disposal plant. All federal, state, and local environmental regulations must be observed. Slow addition to sodium bicarbonate solution in a glass or plastic container. Mix slowly in another container containing lots of water. It is inappropriate and possibly dangerous to the environment to dispose of chemical wasteby flushing them down the toilet or discarding them to the trash

• 予防処置

  Acetyl bromide is combustible and emits irritating or toxic fumes (or gases) in a fire. It should have no contact with naked flames or water. During use, occupational workers should use protective gloves, protective clothing, a face shield or eye protection in combination with breathing protection and should not eat, drink, or smoke. Acetyl bromide decomposes on heating and produces toxic and corrosive fumes, such as hydrogen bromide and carbonyl bromide. It reacts violently with water, methanol, or ethanol to form hydrogen bromide. Acetyl bromide attacks and damages many metals in the presence of water.

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