D-(+)-トレハロース二水和物

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

D-(+)-トレハロース二水和物 価格

D-(+)-トレハロース二水和物 化学特性,用途語,生産方法

• 外観

  白色, 結晶～粉末

• 定義

  本品は、次の化学式で表される二糖類である。

• 溶解性

  水に溶け、エタノールに溶けにくく、ジエチルエーテルにほとんど溶けない。

• 無機性値/有機性値

  990/120

• 用途

  糖研究用。

• 化粧品の成分用途

  保水剤、皮膚コンディショニング剤、香味剤

• 説明

  Trehalose is a natural non-reducing disaccharide composed of two α-glucose units. It is found in all major groups of organisms except vertebrates, has biological functions as an osmolyte, storage reserve, and stress protectant, and has diverse commercial applications. Trehalose can also induce or enhance autophagy.

• 使用

  D(+)-Trehalose dihydrate is used in many processed foods as well as in biopharmaceutical monoclonal antibody formulations, it is also used as a protein stabilize.

• 調製方法

  Trehalose is prepared from liquefied starch by a multistep enzymatic process. The commercial product is the dihydrate.

• 応用例（製薬）

  D(+)-Trehalose dihydrate is used for the lyoprotection of therapeutic proteins, particularly for parenteral administration. Other pharmaceutically relevant applications include use as an excipient for diagnostic assay tablets; for stabilization during the freeze–thaw and lyophilization of liposomes; and for stabilization of blood cells, cosmetics, and monoclonal antibodies. Trehalose may also be used in formulations for topical application.

• 安全性

  Trehalose is used in cosmetics, foods, and parenteral and nonparenteral pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient.
  In the gut, trehalose is rapidly metabolized to glucose by the specific enzyme trehalase. A small minority of the population exhibits a primary (hereditary) or secondary (acquired) trehalase deficiency and thus may experience intestinal discomfort after ingestion of excessive amounts of trehalose owing to the osmotic activity of undigested trehalose in the gut. However, smaller amounts of trehalose are tolerated by such individuals without any symptoms.
  Trehalose is used as a sweetener and is reported to have substantially less cariogenic potential than sucrose.
  LD50 (dog, IV): >1 g/kg
  LD50 (dog, oral): >5 g/kg
  LD50 (mouse, IV): >1 g/kg
  LD50 (mouse, oral): >5 g/kg
  LD50 (rat, IV): >1 g/kg
  LD50 (rat, oral): >5 g/kg

• Source

  D(+)-Trehalose dihydrate is a natural alpha-linked disaccharide that is also referred to as mycose or tremalose. It is found naturally in plants and microorganisms such as grasshoppers, shrimp, butterflies and bees.

• 貯蔵

  Trehalose is a relatively stable material. At 60°C for 5 hours it loses not more than 1.5% w/w of water (the dihydrate water of crystallization is retained). Open stored powder may liquefy at high relative humidity (≥90%).
  Trehalose should be stored in a cool, dry place in a well-sealed container.

• 純化方法

  α,α-D(+)-Trehalose crystallises (as the dihydrate) from aqueous EtOH. Dry it at 13o. For the anhydrous compound dissolve 10g in pyridine (200mL) and distil off this solvent at atmospheric pressure, and when the temperature rises to 115.3o all the H2O is removed and 73mL of distillate is collected. Most of the anhydrous material crystallises out at this stage. The crystals are collected (6.8g), washed with Et2O to give 6.1g of anhydrous product. Higher yields are obtained by slightly more prolonged distillation. [Birch J Chem Soc 3489 1965, X-ray cryst: Brown et al. Acta Cryst 28 3145 1972, Beilstein 17/8 V 3.]

• 不和合性

  D(+)-Trehalose dihydrate is incompatible with strong oxidizing agents, especially in the presence of heat.

• 規制状況(Regulatory Status)

  GRAS listed. In the UK trehalose may be used in certain food applications. Included in parenteral and nonparenteral investigational formulations.

D-(+)-トレハロース二水和物 生産企業

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D-(+)-トレハロース二水和物 スペクトルデータ(¹HNMR、FT-IR、IR、Raman)

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