2-(アミノメチル)フェノール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

2-(アミノメチル)フェノール 価格

2-(アミノメチル)フェノール 化学特性,用途語,生産方法

• 用途

  ・金属ベリリウム：宇宙航空材料、原子炉の反射体、減速材、エックス線管球の窓 ・酸化ベリリウム：原子炉の反射体、減速材、金属融解用るつぼ、電子工業用のマイクロモジュール、パワーチューブなどの部品、ロケット・ミサイルの熱シンク板、セラミックス磁器、半導体 ・ベリリウム銅母合金：バネ材料、溶接の電極材、スイッチ部品、プラスチックなどの成形用金型、保安用安全工具など

• 説明

  2-Hydroxybenzylamine (2-HOBA), also known as salicylamide, is a potent γKA scavenger that scavenges γKAs 980-fold faster than the formation of γKA protein adducts and therefore protects cells from the deleterious effects of γKA adducts. 2-HOBA is currently being developed as a nutritional supplement to help protect against the development of conditions associated with dicarbonyl electrophile formation, such as the cognitive decline observed with Mild Cognitive Impairment or Alzheimer's disease.

• 化学的特性

  white to light yellow crystal powder.

• 使用

  2-Hydroxybenzylamine is a potent γ-ketoaldehyde scavenger that has been shown to protects cardiac sodium channel (NaV1.5) from oxidant-induced inactivation.

• 調製方法

  A simplified method for extracting 2-hydroxybenzylamine from buckwheat is as follows:
  1. Dry the roots, stems, and seeds of buckwheat separately. Grind them into a powder using liquid nitrogen.
  2. Mix the powder with deionized water and adjust the pH of the solution to 5.0. Add an enzyme mixture consisting of cellulase and pectinase, with a weight ratio of 2:1 to the powder. Perform enzymatic hydrolysis at a temperature of 25°C for 40 minutes. Filter the mixture after hydrolysis.
  3. Mix the filter residue obtained in step 2 with 95% ethanol using a solid-liquid ratio of 1g:10mL. Perform ultrasonic extraction at an ultrasound power density of 100W/cm2, ultrasound frequency of 30kHz, extraction temperature of 20°C, and extraction time of 30 minutes. Repeat the extraction process three times, filter the extracts, and combine them.
  4. Concentrate the supernatant obtained in step 3 under reduced pressure to obtain a Chemicalbook extract. Add a 3 wt% sodium hydroxide solution to dissolve the extract. Filter the solution to obtain the filtrate.
  5. Adjust the filtrate obtained in step 4 to pH 3 using hydrochloric acid, resulting in an adjusted solution. Pass the adjusted solution through an NDA-150 resin column at a temperature of 20°C and a flow rate of 10 BV/h until saturated adsorption is achieved.
  6. After reaching saturated adsorption, elute the filtrate obtained in step 4 with an 8 wt% sodium hydroxide solution at 50°C and a flow rate of 2 BV/h. Collect twice the volume of the column volume. Then, elute the filtrate obtained in step 5 with a 3 wt% sodium hydroxide solution at 50°C and a flow rate of 2 BV/h. Collect once the volume of the column volume. Lastly, elute the filtrate obtained in step 5 with water at 60°C and a flow rate of 3 BV/h. Collect once the volume of the column volume. Combine the three eluents.
  7. Concentrate the combined eluents under reduced pressure and recrystallize them using edible alcohol. Separate the crystals to obtain 2-hydroxybenzylamine.

• Synthesis Reference(s)

  Tetrahedron, 48, p. 4301, 1992 DOI: 10.1016/S0040-4020(01)80441-5

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