ヒアルロン酸ナトリウム

ヒアルロン酸ナトリウム 価格

MSDS Information

• Hyaluronic acid sodium salt

ヒアルロン酸ナトリウム 化学特性,用途語,生産方法

• 外観

  白色からうすい黄色、結晶性粉末～粉末又は顆粒

• 定義

  本品は、ヒアルロン酸(*)のナトリウム塩である。参照表示名称：ヒアルロン酸

• 溶解性

  水溶状：試験適合水に溶ける。

• 化粧品の成分用途

  皮膚コンディショニング剤

• 化学的特性

  The PhEur 6.3 describes sodium hyaluronate as the sodium salt of hyaluronic acid, a glycosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units. Sodium hyaluronate occurs as white to off-white powder or granules. It is very hygroscopic.

• 使用

  sodium hyaluronate is used as a humectant to increase moisture in the skin, it may also serve as an emulsifier. Sodium hyaluronate is capable of binding 1,800 times its own weight in water. It is the sodium salt of hyaluronic acid and is the most commonly used form.

• 主な応用

  Sodium Hyaluronic is is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. Sodium hyaluronate is widely used as follows:
  antifungal agent.
  prevents thromboembolic complications.
  aldosterone antagonist used as an adjunct in the management of chronic heart failure.
  suitable as substrate for hyaluronidase.
  Surgical aid (ophthalmological).

• 定義

  Sodium Hyaluronate is a polysaccharide of linear and repeating structural units of the disaccharide D-glucuronic acid and N-acetylD-glucosamine. Hyaluronic acid in human body usually present as polymers with several million molecular weight, and the structural difference by the animal species has not been confirmed.

• 調製方法

  Sodium hyaluronate occurs naturally in vitreous humor, serum, chicken combs, shark skin, and whale cartilage; it is usually extracted and purified from chicken combs. It may also be manufactured by fermentation of selected Streptococcus zooepidemicus bacterial strains; sodium hyaluronate is removed from the fermentation medium by filtration and purified by ultrafiltration. It is then precipitated with an organic solvent and dried.

• 応用例（製薬）

  Sodium hyaluronate is the predominant form of hyaluronic acid at physiological pH. The name hyaluronan is used when the polysaccharide is mentioned in general terms, and in the literature the terms hyaluronic acid and sodium hyaluronate are used interchangeably.
  Hyaluronan is used therapeutically to treat osteoarthritis in the knee, and is an effective treatment for arthritic pain. Crosslinked hyaluronan gels are used as drug delivery systems.
  Hyaluronan is the most common negatively charged glycosaminoglycan in the human vitreous humor, and is known to interact with polymeric and liposomal DNA complexes, where hyaluronan solutions have been shown to decrease the cellular uptake of complexes.(4) This is useful for enhancing the availability and retention time of drugs administered to the eye. It is immunoneutral, which makes it useful for the attachment of biomaterials for use in tissue engineering and drug delivery systems; it also has important applications in the fields of vascosurgery and vascosupplementation.

• 安全性

  Sodium hyaluronate is used in cosmetics and in topical, parenteral, and ophthalmic pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material. Sodium hyaluronate has been reported to be an experimental teratogen.
  LD50 (mouse, IP): 1.5 g/kg
  LD50 (rabbit, IP): 1.82 g/kg
  LD50 (rat, IP): 1.77 g/kg

• 貯蔵

  Sodium hyaluronate should be stored in a cool, dry place in tightly sealed containers. The powder is stable for 3 years if stored in unopened containers.

• 規制状況(Regulatory Status)

  Included in the FDA Inactive Ingredients Database (topical gel preparation).

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