2,3-ジクロロピリジン

化学名:2,3-ジクロロピリジン

CAS番号.2402-77-9

英語名:2,3-Dichloropyridine

CBNumberCB4110338

MFC5H3Cl2N

MW147.99

别名

2,3-ジクロロピリジン

2-クロロ-3-クロロピリジン

2,3‐ジクロロピリジン

2,3-ジクロロピリジン物理性質

融点	64-67 °C (lit.)
沸点	242.42°C (rough estimate)
比重(密度)	1.5159 (rough estimate)
屈折率	1.5500 (estimate)
貯蔵温度	Inert atmosphere,Room Temperature
酸解離定数(Pka)	-0.63±0.10(Predicted)
外見	結晶性粉末
色	白～ややベージュ
水溶解度	わずかに溶ける
BRN	109811
InChI	InChI=1S/C5H3Cl2N/c6-4-2-1-3-8-5(4)7/h1-3H
InChIKey	MAKFMOSBBNKPMS-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=CC=C1Cl
CAS データベース	2402-77-9(CAS DataBase Reference)

安全性情報

危険有害性情報のコード(GHS)

外観
白色～うすい褐色、結晶性粉末～粉末
使用上の注意
アルゴン封入
化学的特性
White to slightly beige crystalline powder
使用
2,3-Dichloropyridine is used as a reagent for the preparation of substituted 3-(5-membered heterocycle-carboxamido)pyridine derivatives for treatment of autoimmune and inflammatory diseases. Also in the synthesis, crystal structure and biological activity of novel anthranilic Diamide insecticide with propargyl ether.
主な応用
As an important fine chemical intermediate, 2,3-Dichloropyridine has been usually applied to the field of pesticide and medicine research.
危険性
2,3-Dichloropyridine is irritating to skin and eyes. It is also irritation to tissues of the mucous membranes and upper respiratory tract.
合成
2,3-dichloropyridine is synthesized from 2-chloronicotinic acid via amidation, Hofmann degradation, diazotization and Sandmeyer reaction.
Structure and conformation
The complete mol-ecule of 2,3-Dichloropyridine, C5H3Cl2N, is generated by crystallographic twofold symmetry, which forces the pyridine N atom and the opposite C—H group to be statistically disordered. In the crystal, weak aromatic π–π stacking [centroid–centroid separation = 3.805 (4)Å and slippage = 1.704Å] leads to [100] stacks of mol-ecules. Short Cl···Cl contacts [3.334 (3)Å] are also observed. Colourless prisms were grown from ethanol.

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