塩化トリジヘキセチル

塩化トリジヘキセチル 化学特性,用途語,生産方法

• 効能

  鎮痙薬, ムスカリン受容体拮抗薬

• 使用

  Tridihexethyl Chloride, is an anticholinergic, antimuscarinic and antispasmodic drug.

• 一般的な説明

  Tridihexethyl chloride,3-cyclohexyl-3-hydroxy-3-phenylpropyl)triethylammoniumchloride (Pathilon), is a white, bitter, crystalline powderwith a characteristic odor. The compound is freely soluble inwater and alcohol, with aqueous solutions being nearly neutralin reaction.
  Although this drug, introduced in 1958, has ganglionblockingactivity, its peripheral atropine-like activity predominates;therefore, its therapeutic application has beenbased on the latter activity. It possesses the antispasmodicand the antisecretory activities characteristic of this group,but because of its quaternary character, it is valueless in relievingParkinson syndrome.

• 臨床応用

  tridihexethyl chloride is useful for adjunctive therapy in a wide varietyof GI diseases, such as peptic ulcer, gastric hyperacidity,and hypermotility and spastic conditions, such as spasticcolon, functional diarrhea, pylorospasm, and other relatedconditions. Because its action is predominantly antisecretory,it is more effective in gastric hypersecretion than in hypermotilityand spasm. It is best administered intravenouslyfor the latter conditions.
  The side effects usually found with effective anticholinergictherapy occur with the use of this drug. These are drynessof mouth, mydriasis, and such. As with other anticholinergics,care should be exercised when administering the drug topatients with glaucomatous conditions, cardiac decompensation,and coronary insufficiency. It is contraindicated inpatients with obstruction at the bladder neck, prostatic hypertrophy,stenosing gastric and duodenal ulcers, or pyloric orduodenal obstruction.

塩化トリジヘキセチル 生産企業

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