2-ブロモピリジン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

  H310：皮膚に接触すると生命に危険

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P262：眼、皮膚、衣類につけないこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

2-ブロモピリジン 価格

MSDS Information

• 2-Bromopyridine

2-ブロモピリジン 化学特性,用途語,生産方法

• 外観

  無色〜赤褐色, 澄明の液体

• 溶解性

  水に可溶 (20.8g/L, 20℃)。エタノール, アセトンに易溶。エタノール及びアセトンに溶け、水に溶けにくい。

• 用途

  有機合成原料。

• 化学的特性

  light yellow oily or dark red liquid. miscible with ethanol, ether, benzene and pyridine, still soluble in water.

• 使用

  2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist.

• 製造方法

  2-Bromopyridine is synthesized from 2-aminopyridine by bromination. In industrial production, hydrobromic acid (over 48%) is first cooled to below 0°C, 2-aminopyridine is slowly added, and then liquid bromine is added dropwise in a salt bath under freezing, and the rate of addition is to control the reaction temperature below -5°C appropriate. After adding, add sodium nitrite aqueous solution dropwise, control the reaction temperature to be below 0°C, stir for 20-30min, dropwise add 50% sodium hydroxide solution, extract the reaction solution with ether, wash with water, dry with anhydrous sodium sulfate, filter, and recover Diethyl ether, the residue was distilled under reduced pressure, and the 88°C-94°C/3333Pa fraction was collected to obtain the finished product of 2-bromopyridine with a yield of 83.8%.

• 反応性

  2-Bromopyridine reacts with butyllithium to give 2-lithiopyridine, which is a versatile reagent.Pyrithione can be prepared in a two-step synthesis from 2-bromopyridine by oxidation to the N-oxide with a suitable peracid followed by substitution using either sodium dithionite or sodium sulfide with sodium hydroxide to introduce the thiol functional group.

• 純化方法

  Dry 2-bromopyridine over KOH for several days, then distil it from CaO under reduced pressure, and taking the middle fraction. [Beilstein 20/5 V 422.]

2-ブロモピリジン 上流と下流の製品情報

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2-ブロモピリジン スペクトルデータ(¹HNMR、¹³CNMR、IR1、MS、Raman)

109-04-6, 2-ブロモピリジン キーワード