4-アミノフェニルアルソン酸 ナトリウム

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

  H331：吸入すると有毒

  H350：発がんのおそれ

  H400：水生生物に強い毒性

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P271：屋外または換気の良い場所でのみ使用すること。

  P273：環境への放出を避けること。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

  P304+P340：吸入した場合：空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。

  P311：医師に連絡すること。

  P321：特別な処置が必要である（このラベルの．．． を見よ）。

  P330：口をすすぐこと。

  P391：漏出物を回収すること。

  P403+P233：換気の良い場所で保管すること。容器を密閉 しておくこと。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

4-アミノフェニルアルソン酸 ナトリウム 価格

4-アミノフェニルアルソン酸 ナトリウム 化学特性,用途語,生産方法

• 外観

  白色～うすい黄色粉末～結晶

• 一般的な説明

  A white crystalline, odorless powder. Slightly denser than water. Contact may irritate skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals.

• 空気と水の反応

  Soluble in water.

• 健康ハザード

  TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

• 火災危険

  Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

• 応用例（製薬）

  Bechamp,teaching medicinal chemistry at the University of Montpellier, synthesised in 1863 a compound from aniline and arsenic acid, which became known later as Atoxyl. The name Atoxyl stems from its decreased toxicity. Bechamp characterised his compound as an anilide.
  In 1905, Thomas and Breinl showed that Atoxyl was effective in the treatment of trypanosomas, mainly Trypanosoma brucei gambiense-the cause of the African sleeping sickness, which was the main health problem around that time in Africa. Nevertheless, very high doses were required to show any pronounced effect, and as a result severe side effects such as blindness and damage to the optical nerve were common issues.
  Inspired by this research, Ehrlich hired the chemist Bertheim in 1905. Bertheim revised the structure of Atoxyl and the correct chemical formula was assigned. Atoxyl was identified as an p-anilinyl arsenic acid derivative on the basis of its properties to reduce Tollen’s reagent [Ag(NH₃)₂]⁺ to metallic silver and its potential use to synthesise the corresponding diazo dye.

• 安全性プロファイル

  Poison by subcutaneous route. Can cause blindness. When heated to decomposition it emits very toxic fumes of As and NOx.

4-アミノフェニルアルソン酸 ナトリウム 生産企業

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