5-アミノ-N-ブチル-2-(2-プロピニルオキシ)ベンズアミド

5-アミノ-N-ブチル-2-(2-プロピニルオキシ)ベンズアミド 化学特性,用途語,生産方法

• Originator

  Parsalmide,Shanghai Lansheng Corporation

• Manufacturing Process

  5-Acetylamino-2-acetoxybenzoyl chloride was obtained by reaction of 5acetylamino-2-acetoxy-benzoic acid with thionylchloride.
  5-Acetylamino-N-butyl-2-hydroxybenzamide was produced in the result of treatment of 5-acetylamino-2-acetoxybenzoyl chloride with butylamine in the presence of sodium hydroxide
  5-Acetamino-N-(n-butyl)-2-propargyloxybenzamide was obtained by reaction of 5-acetylamino-N-butyl-2-hydroxybenzamide with propargylbromide in the presence of sodium, isopropyl alcohol and sulfuric acid.
  28.8 g (0.1 mole) 5-acetamino-N-(n-butyl)-2-propargyloxybenzamide in 320 ml of 4 N sulfuric acid was heated, under stirring, at 90°-95°C for 2 h. The clear solution was cooled and its pH adjusted to 1 with 1 N NaOH; after filtering, further alkali was subsequently added until a pH of 10 was obtained. At this point the product was separated by filtration and recrystallized from ethanol at 60°C to give 16.6 g (a yield of 68%) of chromatographically pure 5-amino-N-(n-hutyl)-2-propargyloxybenzamide; melting point 85°-87°C.

• Therapeutic Function

  Muscle relaxant, Antiinflammatory, Analgesic

5-アミノ-N-ブチル-2-(2-プロピニルオキシ)ベンズアミド 上流と下流の製品情報

5-アミノ-N-ブチル-2-(2-プロピニルオキシ)ベンズアミド 生産企業

Global(5)Suppliers

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