アデホビル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

• 注意書き

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

アデホビル 価格

アデホビル 化学特性,用途語,生産方法

• 効能

  抗ウイルス薬, 逆転写酵素阻害薬

• 化学的特性

  Pale Brown Solid

• 使用

  Adefovir has been used to study its anti-retro viral effect on porcine endogenous retrovirus (PERV) activity.

• 獲得抵抗性

  It has a lower propensity to induce drug resistance than lamivudine. Clinical trials of patients receiving 48 weeks of therapy did not identify any cases of resistance. Longer courses yield resistant strains of HBV with mutations in the DNA polymerase gene; other rare variants of resistant strains have been identified. Lamivudine-resistant strains of HBV retain susceptibility to adefovir.

• 応用例（製薬）

  A nucleotide analog of adenosine monophosphate, administered orally as its prodrug, adefovir dipivoxil.

• 薬物動態学

  Oral absorption： c. 60%
  C_max 10 mg/kg oral： 18.4 ng/mL
  Plasma half-life： c. 7.5 h.
  Volume of distribution： 392 mL/kg
  Plasma protein binding： Not known
  The prodrug is metabolized to adefovir, which is excreted by the kidneys and therefore requires dose adjustment in patients with impaired renal function. It does not induce cytochrome P₄₅₀ at standard doses and does not influence the metabolism or plasma concentrations of the other licensed medications used in the treatment of hepatitis B.

• 臨床応用

  Treatment of chronic hepatitis B virus infection in patients >12 years of age

• 副作用

  It is generally well tolerated, with headache, pharyngitis, abdominal pain and peripheral neuropathy being the most common side effects. Nephrotoxicity has been observed in some patients, with those receiving higher doses and longer courses of therapy at greater risk. Exacerbation of hepatitis has been reported in patients immediately following discontinuation of treatment. Most exacerbations occur within 12 weeks of stopping therapy, and elevations of alanine aminotransferase (ALT) up to 10 times the upper limit of normal can be observed in over 25% of patients. Lactic acidosis has been reported in a few patients and is an indication for immediate discontinuation.

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アデホビル スペクトルデータ(¹HNMR)

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