L-イソロイシン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P271：屋外または換気の良い場所でのみ使用すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

L-イソロイシン 価格

MSDS Information

• (2S,3S)-2-Amino-3-methylpentanoic acid

L-イソロイシン 化学特性,用途語,生産方法

• 外観

  白色～ほとんど白色粉末～結晶

• 定義

  本品は、次の化学式で表されるアミノ酸である。

• 解説

  L-イソロイシン，2-amino-3-methylvaleric acid．C6H13NO2(131.18)．略称IleまたはI．種々のタンパク質，ペプチドに構成アミノ酸として含まれている．必須アミノ酸の一つ．大豆ミール，甜(てん)菜糖廃液，カゼインなどの加水分解液より等電点沈殿法，アゾベンゼン-p-スルホン酸塩法で分離する．発酵法によっても生産される．"不斉炭素原子を2個含むので，二つのラセミ体が存在する．L-イソロイシンの熱分解によって得られる光学活性アミルアミンは，発酵アミルアルコールから導かれるものと同じであるから，これらのβ位の立体配置は等しいことがわかる．D,L-イソロイシンは2-ブロモ-3-メチル吉草酸から種々の方法により合成できる．L-イソロシンは，斜方晶りん片状結晶で苦味をもつ．融点284 ℃．[α]_D²⁰"＋11.29°(水)．pK1 2.36，pK2 9.68．pI6.02．水に難溶，熱エタノールに微溶，他の有機溶媒に不溶．[CAS 73-32-5]

  森北出版「化学辞典（第2版）
  

• 化粧品の成分用途

  ヘアコンディショニング剤、皮膚コンディショニング剤

• 効能

  イソロイシン補充薬

• 説明

  Crystalline leaflets or a white, crystalline powder having a bitter taste. It is soluble in 25 parts of water, slightly soluble in hot alcohol, and soluble in diluted mineral acids and in alkaline solutions. It sublimes at between 168°C and 170°C, and melts with decomposition at about 284°C. The pH of a 1 in 100 solution is between 5.5 and 7.0.
  Absolute: The absolute is prepared by alcoholic extraction of the concrete in approximately 55 to 60% yields. The absolute consists of a semisolid, olive-green mass with a characteristic ambergris odor.
  Resinoid and Resin Absolute: The resinoid consists of the hydro carbon extract of the crude resin. The resin absolute consists of the alcoholic extract of the crude labdanum resin. Since this prod uct is a semisolid, nonpourable mass, a high-boiling, odorless solvent may be added prior to evaporation of the alcohol to prepare a pourable liquid.

• 化学的特性

  White crystalline powder

• 使用

  L-Isoleucine, also known as Isoleucine, is an amino acid that is an isomer of leucine. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.
  L-Isoleucine is one of the essential amino acids that cannot be made by the body and is known for its ability to help endurance and assist in the repair and rebuilding of muscle. This amino acid is important to body builders as it helps boost energy and helps the body recover from training.
  L-Isoleucine is also classified as a branched-chain amino acid (BCAA). There are three branched-chain amino acids in the body, with the others being L-Valine, and L-Leucine, and all of them help promote muscle recovery after exercise. Isoleucine is actually broken down for energy within the muscle tissue.

• 調製方法

  An advantageous fermentation method for production of L-isoleucine is the use of chemically synthesized substrates that only require a few steps to be converted to L-isoleucine. Among these the natural precursors 2-ketobutyrate or D,L-2-hydroxybutyrate have been used for the production with Corynebacterium glutamicum. A leucine requiring mutant of Corynebacterium glutamicum, with increased D-lactate utilization and consuming D,L-2-hydroxybutyrate, accumulates 13.4 g/L L-isoleucine. However, exploitation of this process is hampered by formation of byproducts. Sugar based L-isoleucine processes have been developed with strains of Corynebacterium glutamicum Serratia marcescens, and Escherichia coli. The mutant Escherichia coli H- 8285, being resistant to thiaisoleucine, arginine hydroxamate, and D,L-ethionine accumulates 26 g/L L-isoleucine in 45 h in a fed-batch process. Introduction of resistance to 6-dimethylaminopurine in strain H-8285 resulted in a mutant Escherichia coli H-8461 that increased L-isoleucine accumulation to 30.2 g/L. The biosynthesis of L-isoleucine has been investigated in detail on the level of involved genes, thus recombinant strains are being constructed with high productivity and selectivity. An appropriate balance of homoserine dehydrogenase and threonine dehydratase activities in the construct Corynebacterium glutamicum DR17/pECM3::ilvA (V323A) with feedback-resistant aspartate kinase create a specific productivity of 0.052 g L-isoleucine per gram dry biomass per hour. The recombinant strain Escherichia coli AJ13100 produces L-isoleucine from glucose with high selectivity in 30% yield.
  

• 定義

  ChEBI: The L-enantiomer of isoleucine.

• 副作用

  L-Isoleucine is generally considered a safe ingredient. The side effects may: Intake of Isoleucine can lead to nausea. Large doses can result in a stomach upset and indigestion.

• 概要

  必須アミノ酸の一種

• 純化方法

  Crystallise L-isoleucine from H2O by addition of 4 volumes of EtOH or from aqueous MeOH. It sublimes at 170-181o/0.3mm with 99.7% recovery, unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 1 p 183-191, Vol 3 pp 2043-2073 1961, Huffman & Ingersoll J Am Chem Soc 73 3366 1951, Beilstein 4 IV 2775.]

L-イソロイシン 上流と下流の製品情報

L-イソロイシン 生産企業

Global(1052)Suppliers

L-イソロイシン スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

73-32-5, L-イソロイシン キーワード