2'-O-メチルシチジン(N-AC) 3'-ホスホアミダイト [BOTTLE FOR AKTA] 化学構造式

2'-O-メチルシチジン(N-AC) 3'-ホスホアミダイト [BOTTLE FOR AKTA]

化学名:2'-O-メチルシチジン(N-AC) 3'-ホスホアミダイト [BOTTLE FOR AKTA]

CAS番号.199593-09-4

英語名:DMT-2′O-Methyl-rC(ac) Phosphoramidite

CBNumberCB21871625

MFC42H52N5O9P

MW801.86

MOL File199593-09-4.mol

别名

2'-O-メチルシチジン(N-AC) 3'-ホスホアミダイト [BOTTLE FOR AKTA]

DMT-2'O-メチル-RC(AC) ホスホロアミダイト

2'-O-メチルシチジン(N-AC) 3'-ホスホアミダイト [BOTTLE FOR AKTA]物理性質

融点	102 - 104°C
貯蔵温度	Sealed in dry,2-8°C
溶解性	DMSO（微量）、メタノール（微量）
外見	粉
酸解離定数(Pka)	10.18±0.20(Predicted)
色	ホワイトからオフホワイト
由来生物	non-animal source (no BSE/TSE risk)
InChIKey	WNWUMIPFLOKTEZ-UAQIPLLRSA-N
SMILES	O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(C)=O)=NC2=O)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N \|&1:25,27,39,42,r\|

安全性情報

Sフレーズ	24/25
WGK Germany	3
HSコード	29349990

危険有害性情報のコード(GHS)

2'-O-メチルシチジン(N-AC) 3'-ホスホアミダイト [BOTTLE FOR AKTA] 価格

製品番号	包装	価格	製品説明	購入
富士フイルム和光純薬株式会社(wako) W01CHGANP-6756[EX]	250mg	￥10800		購入
富士フイルム和光純薬株式会社(wako) W01CHGANP-6756[EX]	500mg	￥19400		購入
富士フイルム和光純薬株式会社(wako) W01CHGANP-6756[EX]	5g	￥157700		購入
富士フイルム和光純薬株式会社(wako) W01CHGANP-6756[EX]	10g	￥283900		購入
富士フイルム和光純薬株式会社(wako) W01CHGANP-6756[AKTA]	250mg	￥10800	2'-O-メチルシチジン(N-Ac) 3'-ホスホアミダイト [Bottle for Akta]	購入

2'-O-メチルシチジン(N-AC) 3'-ホスホアミダイト [BOTTLE FOR AKTA] 化学特性,用途語,生産方法

使用
2''-OMe-Ac-C Phosphoramidite (CAS# 199593-09-4) is a nucleotide used in the solid-phase synthesis of phosphorothioate oligonucleotides using sulfurization byproducts for in situ capping.
主な応用
2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rC(ac) Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules
一般的な説明
DMT-2′O-Methyl-rC(ac) Phosphoramidite is one of the 2′O-Methyl RNA monomers that feature methoxy groups at the 2′-position. Themethoxy groups are perfectly stable in all conditions employed in theassembly of oligonucleotides by automated phosphoramidite synthesis, andin all standard alkaline deprotection conditions.Its key features include:
High yield of crude oligonucleotides
Compatible with DNA synthesis
Can be employed together with DNA or RNA phosphoramidites in thesame synthesis to produce mixmer oligonucleotides
Recommended deprotection conditions are 8 hours at 55 °C usingconcentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 °C
Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as nospecial precautions are required to provide protection against nucleolyticdegradation
Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers)
2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry

2'-O-メチルシチジン(N-AC) 3'-ホスホアミダイト [BOTTLE FOR AKTA] 生産企業

199593-09-4, 2'-O-メチルシチジン(N-AC) 3'-ホスホアミダイト [BOTTLE FOR AKTA] キーワード

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