アリザプリド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H312：皮膚に接触すると有害

  H332：吸入すると有害

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

アリザプリド 化学特性,用途語,生産方法

• 効能

  制吐薬, ドパミンD2受容体拮抗薬

• Originator

  Plitican ,Delagrange ,France ,1981

• Manufacturing Process

  38.6 g (0.2 mol) of 2-methoxy-4,5-azimidobenzoic acid were dissolved in anhydrous toluene and 56 g (0.4 mol) of 1-allyl-2-amino-methylpyrrolidine were added. The mixture was heated to 50°C and then 42 g (0.3 mol) of phosphoric anhydride were added. The mixture was warmed at reflux temperature for 3 hours and then cooled to 80°C. After adding water, the aqueous layer was alkalized. The crystals were filtered, washed with water and then dissolved in 450 ml of acetone. After crystallization, the product was 40.4 g (yield 65%) of N-(1'-allyl-2'-pyrrolidylmethyl)-2-methoxy-4,5- azimidobenzamide having a melting point of 139°C were obtained.

• Therapeutic Function

  Neuroleptic, Antiemetic

アリザプリド 上流と下流の製品情報

アリザプリド 生産企業

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