フェノキシベンザミン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 注意書き

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

フェノキシベンザミン 化学特性,用途語,生産方法

• 効能

  血圧降下薬, 末梢血管拡張薬, αアドレナリン受容体拮抗薬

• 使用

  Antihypertensive.

• 主な応用

  Phenoxybenzamine has been the standard agent for blockade before adrenalectomy for pheochromocytoma. However, high cost and limited availability have hampered its use. Selective alpha blockers and calcium channel blockers are increasingly used^[1].

• 世界保健機関（WHO）

  Phenoxybenzamine, a long-acting alpha-adrenoreceptor antagonist, was introduced in 1953 and has been used in a variety of peripheral vascular disorders. In 1982 it was shown to have mutagenic activity and in 1985 it was found to be carcinogenic in the rat. Its approved use was subsequently restricted by several regulatory authorities and phenoxybenzamine is currently used to manage hypertensive episodes associated with phaeochromocytoma, as an adjunct to the short-term management of urinary retention due to neurogenic bladder, in the short-term treatment of benign prostatic hypertrophy in patients awaiting surgery, and in inoperable benign prostatic hypertrophy.

• 安全性プロファイル

  Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intravenous and intracerebral routes. Moderately toxic by ingestion. Human reproductive effects by ingestion: spermatogenesis. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cland NOx.

• 純化方法

  The free base is crystallised from pet ether, and the HCl is crystallised from EtOH/diethyl ether. [Beilstein 12 IV 2204.]

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