ジクラズリル

化学名:ジクラズリル

英語名:Diclazuril

CBNumberCB1317293

MFC17H9Cl3N4O2

MW407.64

别名

4-クロロ-α-[2,6-ジクロロ-4-[(2,3,4,5-テトラヒドロ-3,5-ジオキソ-1,2,4-トリアジン)-2-イル]フェニル]ベンゼンアセトニトリル

2-[4-(4-クロロ-α-シアノベンジル)-3,5-ジクロロフェニル]-1,2,4-トリアジン-3,5(2H,4H)-ジオン

ジクラズリル

ジクラズリル物理性質

融点	290.5°
比重(密度)	1.56±0.1 g/cm3(Predicted)
貯蔵温度	Inert atmosphere,Room Temperature
溶解性	DMF: 5mg/mL; DMSO: 5mg/mL; DMSO:PBS (pH 7.2) (1:5): 0.16mg/mL
酸解離定数(Pka)	5.89±0.20(Predicted)
外見	Solid
色	White to Light yellow to Light orange
Merck	14,3080
InChI	InChI=1S/C17H9Cl3N4O2/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24/h1-6,8,12H,(H,23,25,26)
InChIKey	ZSZFUDFOPOMEET-UHFFFAOYSA-N
SMILES	C1(C=C(C(C(C#N)C2=CC=C(Cl)C=C2)=C(Cl)C=1)Cl)N1N=CC(=O)NC1=O
LogP	2.439 (est)
CAS データベース	101831-37-2(CAS DataBase Reference)

安全性情報

危険有害性情報のコード(GHS)

外観
白色〜わずかにうすい黄色, 結晶性粉末〜粉末
溶解性
N,N-ジメチルホルムアミドに溶ける。
用途
HPLC用標準品
効能
抗コクシジウム薬 (家禽用)
化学的特性
Light yellow or off-white powder, almost insoluble in water, slightly soluble in ethanol, ether, soluble in N,N-2 methylformamide (DMF), dimethylsulfone (DMSO), tetrahydrofuran (THF).
使用
Diclazuril is a triazinone antiprotozoal that Nucleotide analog with broad-spectrum anticoccidial activity. It has a control effect on a variety of coccidiosis, and is used to prevent coccidiosis in chickens, ducks, quails, turkeys, geese and rabbits.
主な応用
Diclazuril is a less toxic, orally administered triazine antiprotozoal. It is widely used in veterinary medicine as a feed additive and veterinary drug. It is registered for oral use in broilers and lambs. Its use in cats (one dose of 25 mg/kg BW) is off-label only. It may be used clinically for the treatment of bovine protozoa. It is also used for the treatment of equine protozoan spinal cord encephalitis (EPM) caused by neuronal sarcocysts.
Veterinary Drugs and Treatments
Diclazuril is a coccidiostat. It is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona and as a coccidiostat in broiler chickens. Diclazuril could potentially be useful in treating coccidiosis, Neospora caninum and Toxoplasma infections in dogs or cats.