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3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Structure
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
  • CAS No.86499-96-9
  • Chemical Name:3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
  • CBNumber:CB9777910
  • Molecular Formula:C10H10BrNO
  • Formula Weight:240.1
  • MOL File:86499-96-9.mol
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Property
  • Melting point 164 °C
  • Boiling point 383.2±42.0 °C(Predicted)
  • Density 1.492±0.06 g/cm3(Predicted)
  • Flash point 185.542℃
  • storage temp. Keep in dark place,Sealed in dry,Room Temperature
  • solubility slightly soluble in ethanol, benzene, acetone, insoluble in water
  • pka 13.59±0.40(Predicted)
  • InChI InChI=1S/C10H10BrNO/c11-8-6-5-7-3-1-2-4-9(7)12-10(8)13/h1-4,8H,5-6H2,(H,12,13)
  • InChIKey JMXPGCGROVEPID-UHFFFAOYSA-N
  • SMILES N1C2=CC=CC=C2CCC(Br)C1=O
  • CAS DataBase Reference 86499-96-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319
  • Precautionary statements P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Chemical Properties,Usage,Production

  • Uses 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one is an intermediate in the synthesis of Benazepril Hydrochloride. Benazepril Hydrochloride is a first-line antihypertensive drug recommended by the WHO. It is a chiral drug with excellent clinical efficacy, strong safety and tiny side effects in the international antihypertensive drugs of angiotensin converting enzyme inhibitors.
  • Chemical Properties White or almost white crystalline
  • Preparation The preparation of 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one is as follows:10 parts by weight of the heated melted polyphosphoric acid was added to the drying kettle, With stirring, The above 2-bromo-3,4-dihydro-N-hydroxy- (2H) -naphthalimide was added in portions at a temperature of 60 ° C, Insulation reaction for 20 hours; The reaction solution was added dropwise to 12.5 parts by weight of water to carry out hydrolysis, Still Washed to give 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one crude; 10 parts by weight of methanol and 0.1 part by weight of activated carbon were added, Heating decolorization, After filtration, the filtrate was cooled to 10 ° C for 20 hours, centrifuged, washed and dried to give 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepan-2-one. The purity of the product was 3, 10-bromo-1,3,4,5-tetrahydro-2H-1-benzazepan-2-one as high as 99.6% and the yield was as high as 98%.

    86499-96-9.png

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Suppliers
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3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Spectrum
86499-96-9, 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-oneRelated Search:
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  • C10H10NOBr
  • C10H10BrNO
  • 96499-96-9
  • 68499-96-9
  • 65-71-6
  • 3-溴-1,3,4,5-四氢-2H-1-BENZ氮杂革-2-酮
  • 3-溴-1,3,4,5-四氢-2H-1-苯并氮杂卓-2-酮(BTB)
  • 3-溴-1,3,4,5-四氢-2H-1-苯并氮杂...基本信息 中文名称 3-溴-1,3,4,5-四氢-2H-1-苯并氮杂卓-2-酮 英文名称 3-BROMO-4,5-DIHYDRO-1H-BENZO
  • 3-溴-1.3.4.5-四氢-2H-1-苯并氮杂硫卓-2-酮
  • Α-溴代苯并己内酰胺
  • 3-溴-2,3,4,5-四氢-2-氧-1H-苯并氮杂卓
  • 3-溴-4,5-二氢-1H-苯并[B]氮杂-2-(3H)-酮
  • 3-溴-2,3,4,5-四氢-1H-1-苯并氮杂卓-2-酮
  • 5-四氢-2H-1-苯并氮杂卓-2-酮
  • 3-溴-2,3,4,5-四氢-2H-苯并[B]氮杂卓-2-酮
  • Α-溴苯并己内酰胺
  • 3-溴-1,3,4,5-四氢-2H-1-苯甲酰-2-酮
  • 3-溴-2,3,4,5-四氢-2-氢-2-酮-1-苯并氮杂卓
  • 3-溴-2,3,4,5-四氢-2H-1-苯并氮杂卓-2-酮
  • 3-溴-4,5-二氢-1H-苯并[B]氮杂卓-2(3H)-酮
  • 3-溴-2,3,4,5-四氢-2-氧-1H-1-苯并氮杂卓
  • 3-溴-1,3,4,5-四氢-2H-1-苯并氮杂卓-2-酮
  • Α-溴代苯并己内酰胺
  • 3-溴-2,3,4,5-四氢-2-氧-1H-1-苯并氮杂卓(BTB)
  • 3-溴-1,3,4,5-四氢-2<I>H</I>-1-苯并氮杂卓-2-酮
  • 86499-96-9
  • 3-bromo-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazazepine
  • α-Bromophenylcaprolactam
  • 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazazole-2-one
  • 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one / Benazepril intermediate
  • 3-Bromo-1,3,4,5-tetrahydro-2-h-1-benzacepin–2one
  • 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzoazo-2-one
  • 3-Bromo-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one (Alpha-Bromolactum)
  • 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one (Benazepril API KSM)
  • 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
  • 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one USP/EP/BP
  • 3-Bromo-2,3,4,5-tetrahydro-2-h-1-benzacepin–2one
  • 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one &gt
  • 5-tetrahydro-2H-benzo[b]azepin-2-one
  • 3-bromo-1,3,4,5-tetrahydro-2H-1-benzoazepine-2-on
  • 3-bromo-1,3,4,5-tetrahydro-1-benzazepin-2-one
  • 3-bromo-1,3,4,5-tetrahydro-2H-1-benzoazepine-2-one
  • Intermediate 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
  • 2H-1-Benzazepin-2-one, 3-broMo-1,3,4,5-tetrahydro-

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