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Laurocapram

Chemical properties Penetration enhancer Application References

Laurocapram

CAS No.59227-89-3
Chemical Name:Laurocapram
CBNumber:CB9414646
Molecular Formula:C18H35NO
Formula Weight:281.48
MOL File:59227-89-3.mol

Laurocapram Property

Melting point -7°
Boiling point bp50m 160°
Density 0.906-0.926
refractive index 1.470-1.473
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form Oil
pka -0.43±0.20(Predicted)
color Colourless
Merck 14,5385
LogP 6.570 (est)
CAS DataBase Reference 59227-89-3(CAS DataBase Reference)
FDA UNII 1F3X9DRV9X
EPA Substance Registry System Laurocapram (59227-89-3)

Safety

Safety Statements :24/25
RTECS :CM3995000
HS Code :29339900
Hazardous Substances Data :59227-89-3(Hazardous Substances Data)
Toxicity :LD50 rats, mice (g/kg): 8 i.v., i.p. (Stoughton)

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319-H335
Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338

Laurocapram Price More Price(2)

Brand: TCI Chemicals (India)
Product number: L0317
Product name : Laurocapram
Purity: min. 96.0 %
Packaging: 5ML
Price: ₹2500
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: L0317
Product name : Laurocapram
Purity: min. 96.0 %
Packaging: 25ML
Price: ₹6100
Updated: 2022/05/26
Buy: Buy

Laurocapram Chemical Properties,Usage,Production

Chemical properties Colorless or slightly yellow transparent liquid, insoluble in water, it can form emulsion with water, soluble in various organic solvents.
Penetration enhancer Laurocapram, also known as azone, lauric Lun, N-lauryl caprolactam, quinacridone, nitrogen ketone. Its chemical name is 1-n-dodecyl azetidin-2-one, which is a new high security penetration enhancer. It is colorless transparent liquid at room temperature, slightly viscous, odorless. It can form emulsion with water, soluble in various organic solvents, and it has good lubricity, which promote the hydrophilic and lipophilic drug product activity or cosmetics nutrients to penetrate into the skin, greatly reducing the drug remain time in the stratum corneum, significantly enhancing drug efficacy and cosmetic results. Thus, we can reduce the amount of primary medical and reduce costs. Azone transdermal absorption enhancing effect lags behind.
Laurocapram on hydrophilic and lipophilic drugs have significantly transdermal Aided role. It has good aided effect on many kinds of plant extracts in emulsion state or colloidal state, and alkaloids effect is particularly evident. Transdermal penetration is stronger than dimethyl sulfoxide. 8-bromo cyclic nucleotide containing 1% azone permeability effect is equivalent to 12 times the 50% dimethyl sulfoxide. Often in combination with propylene glycol, synergy, the best use of transdermal concentration of 0.1% to 5%, safe and low toxic, non-irritating. The chemical property is stable, and it is kept up to four years at the room temperature.
It can be considered a decyl methyl sulfoxide with pyrrolidone composite for good novel penetration enhancers, skin irritation. It can promote the drug through the skin barrier corticosteroids, indomethacin, fluorouracil, hydroquinone and many other drugs transdermal absorption, improving local and systemic blood concentration, and improving the bioavailability of the drug. Lipophilic, they have transdermal effect for hydrophilic drugs. It can soften the skin and enhance its permeability. They have anti-inflammatory, analgesic and anti-itching effect. Low toxicity, oral LD50> 7g/kg, it is not compatible with strong acids or Vaseline to avoid reduce the effect.
Application Laurocapram is used as the penetration enhancer in cosmetic preparations and personal-care products. Laurocapram is combined as an excipient (an inert substance) not an active ingredient. Excipients are added to ensure that the shelf-life of the active ingredients can be long enough to be active until internal use. It can be used as a topical smear, massage penetration enhancers; pesticides, as a pro-absorbing agent and sterilization plant growth regulators, pesticides pro penetration; in addition, can be used for coloring and dyeing leather and other areas of accelerator.
References http://www.chemicalland21.com/lifescience/foco/LAUROCAPRAM.htm
Uses antifungal lipopeptide
Uses Laurocapram is a useful intermediate.
Uses Pharmaceutic aid (excipient).