ChemicalBook > CAS DataBase List > BLEOMYCIN A5 HYDROCHLORIDE

BLEOMYCIN A5 HYDROCHLORIDE

BLEOMYCIN A5 HYDROCHLORIDE Structure
BLEOMYCIN A5 HYDROCHLORIDE
  • CAS No.55658-47-4
  • Chemical Name:BLEOMYCIN A5 HYDROCHLORIDE
  • CBNumber:CB9762129
  • Molecular Formula:C57H90ClN19O21S2
  • Formula Weight:1477.03
  • MOL File:55658-47-4.mol
BLEOMYCIN A5 HYDROCHLORIDE Property
  • Melting point >185°C (dec.)
  • storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
  • solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
  • form Solid
  • color White to Pale Yellow
  • Stability Hygroscopic
  • FDA UNII T2UC5J38DD
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H302-H315-H317-H319-H334-H335-H361d
  • Precautionary statements P280-P301+P312-P302+P352-P304+P340+P312-P305+P351+P338-P308+P313

BLEOMYCIN A5 HYDROCHLORIDE Chemical Properties,Usage,Production

  • Uses Bleomycin A5 Hydrochloride is used as an anti-cancer drug used to combat various forms of carcinoma via activated-apoptosis of cancer cells.
  • Biological Activity bleomycin a5 is an anticancer chemotherapeutic that binds dna and induces dna cleavage and strand breaks, it is highly toxic. additionally, this compound induces apoptosis, alters cell cycle regulation, inhibits proliferation, and decreases tumor size in cellular and animal models of hemangioma. bleomycin may also inhibit thioredoxin reductase.
  • in vitro the ic50 of blm alone to the cells was about 2.63 μg/ml. the ic50 of blm was decreased to 1/3.8 and 1/9.5 of 2.63 μg/ml when used in combination with 2.63 μg/ml and 5 μg/ml w-131 [1]. bleomycin a5 induced the activation of a jnk pathway in a dose-dependent manner. after 24h treatment, bleomycin a5 induced dramatic cell death. dapi nuclear staining assay revealed that pd98059 (10 μm) markedly enhanced bleomycin a5-induced apoptosis [2].
  • in vivo in the rats, bleomycin a5 induced pulmonary inflammation and fibrosis, increased the levels of malondialdehyde and tumour necrosis factor-α and enhanced accumulation of collagen in the lungs. rolipram administration significantly attenuated these effects [3].
  • References [1]. zhang h q, he n g, xue s b. effect of bleomycin a5 with calmodulin inhibitor on the proliferation of s-180 cells in vitro[j]. zhongguo yao li xue bao= acta pharmacologica sinica, 1990, 11(5): 470-473.
    [2]. yang l c, yang s h, tai k w, et al. mek inhibition enhances bleomycin a5‐induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities[j]. journal of oral pathology & medicine, 2004, 33(1): 37-45.
    [3]. pan j b, hou y h, zhang g j. rolipram attenuates bleomycin a5‐induced pulmonary fibrosis in rats[j]. respirology, 2009, 14(7): 975-982.
BLEOMYCIN A5 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
BLEOMYCIN A5 HYDROCHLORIDE Suppliers
Global(107)Suppliers
  • Supplier：
    Xiamen AmoyChem Co., Ltd
  • Tel：+86-86-5926051114<br/>+8615060885618
  • Email：sales@amoychem.com
  • Country：China
  • ProdList：6383
  • Advantage：58
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    SIMAGCHEM CORP
  • Tel： +86-13806087780
  • Email：sale@simagchem.com
  • Country：China
  • ProdList：17365
  • Advantage：58
BLEOMYCIN A5 HYDROCHLORIDE Spectrum
55658-47-4, BLEOMYCIN A5 HYDROCHLORIDERelated Search:
  • 合成中间体
  • 原料药
  • 医药原料
  • 化合物
  • 抗疟疾药物
  • 抗肿瘤类药物及免疫抑制剂
  • C57H89N19O21S2xHCl
  • 盐酸平阳霉素试剂原料
  • 博来霉素A5盐
  • 盐酸平阳霉素, >85%
  • 盐酸平阳霉素
  • BLEOMYCIN A5 HYDROCHLORID 盐酸平阳霉素
  • 盐酸平阳霉素(标准品)
  • 55658-47-4
  • Bleomycin A5 hydrochloride, copper complex
  • Bleomycin impurity A5 HCl
  • BLEOMYCIN A5 HYDROCHLORIDE USP/EP/BP
  • Bleomycin A5 HCl Salt
  • BLEOCIN(TM), STREPTOMYCES VERTICILLUS, ＞85%
  • N1-[3-[(4-Aminobutyl)amino]propyl]bleomycinamide hydrochloride
  • N -[3-(4-Aminobutyl)amino]propyl" hydrochloride
  • BLEOCIN(TM), STREPTOMYCES VERTICILLUS
  • BLEOCIN(TM) ANTIBIOTIC
  • BLEOCIN(TM)
  • n(sup1)-(3-((4-aminobutyl)amino)propyl)-bleomycinamidhydrochloride
  • n(sup1)-(3-((4-aminobutyl)amino)propyl)bleomycinamidehydrochloride
  • Bleomycin A5 Hydrochloride Salt
  • Bleomycin A5 Hydrochlorid
  • BleoMycin A5 Hydrochloride(PingyangMycin hydrochloride)
  • Bleomycin A5 Hydrochloride

Home

My