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Pheniramine maleate

Pheniramine maleate Structure
Pheniramine maleate
  • CAS No.132-20-7
  • Chemical Name:Pheniramine maleate
  • CBNumber:CB9727768
  • Molecular Formula:C20H24N2O4
  • Formula Weight:356.42
  • MOL File:132-20-7.mol
Pheniramine maleate Property
  • Melting point 104-108°C
  • Boiling point 489.25°C (rough estimate)
  • Density 1.2233 (rough estimate)
  • refractive index 1.6800 (estimate)
  • storage temp. 2-8°C
  • solubility Very soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
  • form Solid
  • color White
  • Water Solubility >=1 g/100 mL at 24 ºC
  • λmax 262nm(lit.)
  • Merck 14,7235
  • Stability Stable. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference 132-20-7(CAS DataBase Reference)
  • FDA 21 CFR 310.545; 341.12
  • EWG's Food Scores 1
  • FDA UNII NYW905655B
  • EPA Substance Registry System Pheniramine maleate (132-20-7)
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • Safety Statements  :36
  • WGK Germany  :3
  • RTECS  :UT0175000
  • HS Code  :2933399090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P301+P312+P330
Pheniramine maleate Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: PHR2646
  • Product name : Pheniramine Maleate
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging: 300MG
  • Price: ₹17038.55
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: P6902
  • Product name : Pheniramine maleate salt
  • Purity: 
  • Packaging: 5G
  • Price: ₹15382.33
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: P2271
  • Product name : Pheniramine Maleate
  • Purity: 
  • Packaging: 25G
  • Price: ₹9700
  • Updated: 2022/05/26
  • Buy: Buy

Pheniramine maleate Chemical Properties,Usage,Production

  • Chemical Properties white powder
  • Originator Trimeton Maleate, Schering ,US,1948
  • Uses Pheniramine, a H1-receptor antagonist, is an antihistamine with anticholinergic and sedative properties. Pheniramine is used to treat allergic conditions such as hay fever or urticaria.
  • Definition ChEBI: Pheniramine maleate is an organic molecular entity.
  • Manufacturing Process According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the Pheniramine, BP 139°-142°C/1-2 mm. The Pheniramine maleate is produced by reaction with maleic acid.
  • Therapeutic Function Antihistaminic
  • General Description White powder with a faint amine-like odor. Melting point 107°C. pH (1% solution) 4.5-5.5. Used medicinally as an antihistaminic.
  • General Description Pheniramine maleate, 2-[α-[2-dimethylaminoethyl]benzyl]-pyridine bimaleate (Trimeton,Inhiston), is a white crystalline powder, with a faint aminelikeodor, which is soluble in water (1:5) and very soluble inalcohol. This drug is the least potent member of the seriesand is marketed as the racemate. The usual adult dose is 20to 40 mg 3 times daily. It is available in certain combinationproducts.
  • Air & Water Reactions Water soluble.
  • Reactivity Profile Pheniramine maleate gives weakly acidic aqueous solutions. May react with strong oxidizing agents.
  • Fire Hazard Flash point data are not available for Pheniramine maleate, but Pheniramine maleate is probably combustible.
  • Biochem/physiol Actions Pheniramine maleate is a H1 histamine receptor antagonist. It is an alkylamine derivative. Structurally, pheniramine contains a chiral carbon atom with a hydrogen atom. Other substituents include the pyridyl, alkylamine and phenyl groups. It is used as an antiallergic drug for treating the common cold, respiratory allergies, urticaria, and systematic allergic reactions.
  • Side effects Drowsiness, dizziness, dry mouth/nose/throat, headache, upset stomach, constipation, or trouble sleeping may occur. 
Pheniramine maleate Preparation Products And Raw materials
Raw materials
Preparation Products
Pheniramine maleate Suppliers
Global(388)Suppliers
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