General Description
White powder with a faint amine-like odor. Melting point 107°C. pH (1% solution) 4.5-5.5. Used medicinally as an antihistaminic.
Reactivity Profile
PHENIRAMINE MALEATE(132-20-7) gives weakly acidic aqueous solutions. May react with strong oxidizing agents.
Air & Water Reactions
Water soluble.
Fire Hazard
Flash point data are not available for this chemical, but PHENIRAMINE MALEATE is probably combustible.
Chemical Properties
white powder
Originator
Trimeton Maleate, Schering ,US,1948
Uses
A H1 histamine receptor antagonist.
Uses
Antihistaminic;H1 antagonist
Uses
Pheniramine, a H1-receptor antagonist, is an antihistamine with anticholinergic and sedative properties. Pheniramine is used to treat allergic conditions such as hay fever or urticaria.
Uses
Used medicinally as an antihistaminic (merck).
Definition
ChEBI: Pheniramine maleate is an organic molecular entity.
Manufacturing Process
According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the 3-phenyl-3-(2-pyridyl)-N,Ndimethylpropylamine, BP 139°-142°C/1-2 mm. The maleate is produced by reaction with maleic acid.
Therapeutic Function
Antihistaminic
Biochem/physiol Actions
Pheniramine maleate is a H1 histamine receptor antagonist. It is an alkylamine derivative. Structurally, pheniramine contains a chiral carbon atom with a hydrogen atom. Other substituents include the pyridyl, alkylamine and phenyl groups. It is used as an antiallergic drug for treating the common cold, respiratory allergies, urticaria, and systematic allergic reactions.
Side effects
Drowsiness, dizziness, dry mouth/nose/throat, headache, upset stomach, constipation, or trouble sleeping may occur.
References
[1] Patent: CN108164455, 2018, A. Location in patent: Paragraph 0009; 0010; 0058; 0059; 0060; 0062
