Description
Flonicamid is a pyridinecarboxamide insecticide. It inhibits the brown planthopper (
N. lugens) inward-rectifying potassium channel K
ir1 (IC
50 = 0.64 μM). Flonicamid (100 μg/ml) inhibits aphid (
M. persicae) salivation and sap ingestion during feeding on Japanese radish leaves. It induces toxicity in the aphid species
A. gossypii, R. padi, S. graminum, and
L. erysimi (LC
50s = 0.64, 0.74, 0.78, and 2.01 μg/ml, respectively) and rats (LD
50 = ≥844 mg/kg). Formulations containing flonicamid have been used for the control of pest insects in agriculture.
Uses
Flonicamid is a novel insecticide with rapid inhibitory effect against aphid feeding. Useful in cannabis testing kits as a component of pesticide mixes (P698240).
Uses
Flonicamid is an novel insecticide with rapid inhibitory effect against aphid feeding.
Application
With foliar spray application at the rates of 50-100 g a.i./ha, onicamid
exhibits excellent aphicidal activity and also shows good insecticidal
activity against other sucking insect pests such as thrips, white ies,
planthoppers, leafhoppers, plant bugs, and mealybugs in fruit trees,
cereals, rice, potatoes, cotton, vegetables and ornamentals. Flonicamid
soil applications also provide control of the foliar pests mentioned above.
Definition
Flonicamid is a chordotonal modulator and novel systemic insecticide that has been used frequently for controlling a broad range of insect pests. The risk of flonicamid resistance was assessed through laboratory selection and determining inheritance pattern and cross-resistance potential to five insecticides in house fly, Musca domestica L. Very low to high flonicamid resistance in M. domestica populations was found compared with the susceptible strain (SS).
Definition
ChEBI: A pyridinecarboxamide that is nicotinamide substituted by a trifluoromethyl group at position 4 and a cyanomethyl group at the carbamoyl nitrogen atom.
Synthesis
Flonicamid is commercially produced through a multi-step chemical synthesis that begins with the preparation of 4-trifluoromethylnicotinic acid, which serves as the core structural component. This acid is converted into its acid chloride form using reagents like thionyl chloride, enabling it to react with aminoacetonitrile hydrochloride in the presence of a base and a phase-transfer catalyst. The resulting intermediate amide is then treated with aqueous sodium carbonate to yield flonicamid, a compound with high purity and yield.
Mode of action
Flonicamid rapidly inhibits the feeding behavior of aphids, and has
better action through ingestion than by contact.
Its mode of action is different from other insecticides such as neonicotinoids, pymetrozine and pyri uquinazon.
Flonicamid belongs to IRAC Group 29 and is the only insecticide in this
class.
References
[1] MIAOMIAO REN . Block of Kir channels by flonicamid disrupts salivary and renal excretion of insect pests[J]. Insect Biochemistry and Molecular Biology, 2018, 99: Pages 17-26. DOI:
10.1016/j.ibmb.2018.05.007[2] MASAYUKI MORITA. Flonicamid, a novel insecticide with a rapid inhibitory effect on aphid feeding[J]. Pest Management Science, 2007, 63 10: 969-973. DOI:
10.1002/ps.1423[3] M. MORITA N A T Yoneda. Research and development of a novel insecticide, flonicamid[J]. Journal of Pesticide Science, 2014, 39 1: 179-180. DOI:
10.1584/jpestics.j14-05
Pesticide Type
Insecticide
