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Flonicamid is an novel insecticide with rapid inhibitory effect against aphid feeding.

ChEBI: A pyridinecarboxamide that is nicotinamide substituted by a trifluoromethyl group at position 4 and a cyanomethyl group at the carbamoyl nitrogen atom.

Insecticide.

Flonicamid is a pyridinecarboxamide insecticide. It inhibits the brown planthopper (N. lugens) inward-rectifying potassium channel K_ir1 (IC₅₀ = 0.64 μM). Flonicamid (100 μg/ml) inhibits aphid (M. persicae) salivation and sap ingestion during feeding on Japanese radish leaves. It induces toxicity in the aphid species A. gossypii, R. padi, S. graminum, and L. erysimi (LC₅₀s = 0.64, 0.74, 0.78, and 2.01 μg/ml, respectively) and rats (LD₅₀ = ≥844 mg/kg). Formulations containing flonicamid have been used for the control of pest insects in agriculture.

With foliar spray application at the rates of 50-100 g a.i./ha, onicamid exhibits excellent aphicidal activity and also shows good insecticidal activity against other sucking insect pests such as thrips, whiteies, planthoppers, leafhoppers, plant bugs, and mealybugs in fruit trees, cereals, rice, potatoes, cotton, vegetables and ornamentals. Flonicamid soil applications also provide control of the foliar pests mentioned above.

Flonicamid rapidly inhibits the feeding behavior of aphids, and has better action through ingestion than by contact. Its mode of action is different from other insecticides such as neonicotinoids, pymetrozine and pyriuquinazon. Flonicamid belongs to IRAC Group 29 and is the only insecticide in this class.