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KI16425

KI16425 Structure
KI16425
  • CAS No.355025-24-0
  • Chemical Name:KI16425
  • CBNumber:CB9497429
  • Molecular Formula:C23H23ClN2O5S
  • Formula Weight:474.96
  • MOL File:355025-24-0.mol
KI16425 Property
  • Melting point 59.5-60.5 °C
  • Boiling point 623.7±55.0 °C(Predicted)
  • Density 1.353
  • storage temp. -20°C
  • solubility DMSO: 16 mg/mL
  • pka 4.32±0.10(Predicted)
  • form solid
  • color white
  • FDA UNII 83W49JT69B
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26-36
  • WGK Germany  :3
  • HS Code  :29349990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
KI16425 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0971
  • Product name : Ki 16425
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹11571.93
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0971
  • Product name : Ki 16425
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹46731.53
  • Updated: 2022/06/14
  • Buy: Buy

KI16425 Chemical Properties,Usage,Production

  • Description Lysophosphatidic acid (LPA) is a bioactive lipid mediator that signals through five distinct G protein-coupled receptors (LPA1-5). Ki16425 is a LPA receptor antagonist with selectivity for LPA1 and LPA3. It exhibits Ki values of 0.34, 6.5, and 0.93 μM for the human LPA1, LPA2, and LPA3 receptors, respectively, as determined by measuring inositol phosphate production in RH7777-transfected cells. Ki1642, at 10 μM, significantly blocks the response of a variety of cancer cell lines to LPA-induced cell migration.
  • Uses Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3.
  • Uses Ki 16425 has been used as a chemical inhibitor to study the regulation of LPA (lysophosphatidic acid) on LPAR(LPA receptor) subtypes.
  • Definition ChEBI: 3-[({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid is a member of the class of isoxazoles that is the carbamate ester obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)ethyl hydrogen carbonate with the amino group of 3-({[4-(4-amino-3-methyl-1,2-oxazol-5-yl)phenyl]methyl}sulfanyl)propanoic acid. It is a member of isoxazoles, a carbamate ester, a member of monochlorobenzenes, an organic sulfide and a monocarboxylic acid.
  • Biochem/physiol Actions Ki 16425 possesses a short-lived inhibitory activity. It has been studied that Ki 16425 is effective in the inhibition of neuropathic pain‐like behaviors.
  • storage Store at +4°C
  • References [1]. ohta h, sato k, murata n, damirin a, malchinkhuu e, kon j, kimura t, tobo m, yamazaki y, watanabe t, yagi m, sato m, suzuki r, murooka h, sakai t, nishitoba t, im ds, nochi h, tamoto k, tomura h, okajima f. ki16425, a subtype-selective antagonist for edg-family lysophosphatidic acid receptors. mol pharmacol. 2003 oct;64(4):994-1005.
    [2]. ruisanchez é, dancs p, kerék m, németh t, faragó b, balogh a, patil r, jennings bl, liliom k, malik ku, smrcka av, tigyi g, benyó z. lysophosphatidic acid induces vasodilation mediated by lpa1 receptors, phospholipase c, and endothelial nitric oxide synthase. faseb j. 2014 feb;28(2):880-90.
    [3]. su sc, hu x, kenney pa, merrill mm, babaian kn, zhang xy, maity t, yang sf, lin x, wood cg. autotaxin-lysophosphatidic acid signaling axis mediates tumorigenesis and development of acquired resistance to sunitinib in renal cell carcinoma. clin cancer res. 2013 dec 1;19(23):6461-72.
    [4]. david m, sahay d, mege f, descotes f, leblanc r, ribeiro j, clézardin p, peyruchaud o. identification of heparin-binding egf-like growth factor (hb-egf) as a biomarker for lysophosphatidic acid receptor type 1 (lpa1) activation in human breast and prostate cancers. plos one. 2014 may 14;9(5):e97771.
KI16425 Preparation Products And Raw materials
Raw materials
Preparation Products
KI16425 Suppliers
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KI16425 Spectrum
355025-24-0, KI16425Related Search:
  • Inhibitors
  • 抑制剂
  • 生物试剂
  • 合成有机化合物配体
  • 小分子抑制剂，天然产物
  • G蛋白偶联受体&G蛋白
  • LPA抑制剂分子
  • 原料药
  • 化合物KI16425,10 MM DMSO 溶液
  • KI16425,LPA1和LPA3受体拮抗剂
  • 3-((4-(4-(((1-(2-氯苯基)乙氧基)羰基)氨基)-3-甲基异恶唑-5-基)苄基)硫基)丙酸
  • 化合物KI16425
  • KI 16425, 竞争性可逆LPA拮抗剂
  • 3-[[[4-[4-[[[1-(2-氯苯基)乙氧基]羰基]氨基]-3-甲基-5-异恶唑基]苯基]甲基]硫基]丙酸
  • 355025-24-0
  • Ki16425, 10 mM in DMSO
  • Ki 16425, competitive, potent and reversible antagonist to LPA
  • Ki16425 (Debio 0719)
  • KI16425 USP/EP/BP
  • Propanoic acid, 3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]-
  • Debio 0719
  • Ki 16425, 98%, competitive, potent and reversible antagonist to LPA
  • KI-16425; KI 16425
  • CS-88
  • 3-((4-(4-(((1-(2-Chlorophenyl)ethoxy)carbonyl)amino)-3-methylisoxazol-5-yl)benzyl)thio)propano
  • 3-[[4-[4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-methyl-isoxazol-5-yl]phenyl]methylsulfanyl]propanoic acid
  • KI16425;KI-16425; KI 16425
  • Ki16425, >=98%
  • 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl)-3-methylisoxazol-5-yl)benzylthio)propanoic acid
  • KI-6425
  • 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid
  • 3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazoly]phenyl]methyl]thio]-propanoic acid

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