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Trimethylacetic anhydride

Trimethylacetic anhydride Property

Boiling point 193 °C(lit.)
Density 0.918 g/mL at 25 °C(lit.)
vapor pressure 62.1Pa at 25℃
refractive index n20/D 1.409(lit.)
Flash point 135 °F
storage temp. Inert atmosphere,Room Temperature
solubility Miscible with acetonitrile.
form Liquid
color Clear colorless
Sensitive Moisture Sensitive
BRN 386552
InChI InChI=1S/C10H18O3/c1-9(2,3)7(11)13-8(12)10(4,5)6/h1-6H3
InChIKey PGZVFRAEAAXREB-UHFFFAOYSA-N
SMILES C(C)(C)(C)C(=O)OC(=O)C(C)(C)C
LogP 2.15
CAS DataBase Reference 1538-75-6(CAS DataBase Reference)
EPA Substance Registry System Propanoic acid, 2,2-dimethyl-, anhydride (1538-75-6)
UNSPSC Code 12352100
NACRES NA.22

Safety

NFPA 704:

Hazard and Precautionary Statements (GHS)

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Trimethylacetic anhydride Chemical Properties,Usage,Production

Description Trimethylacetic anhydride is a pivalic acid derivative that is used in organic synthesis. The compound's reaction mechanism is believed to be the formation of an alkanoic acid, which reacts with a hydroxyl group to form an anhydride. Trimethyl acetic anhydride has been shown to have pharmacokinetic properties and can be used as a nonsteroidal anti-inflammatory drug. This compound has also been found to have a matrix effect on crystalline cellulose and is capable of forming nitrogen-containing carboxylic acids.
Chemical Properties clear colourless liquid
Uses Trimethylacetic anhydride was used:
- in solid-phase oligonucleotide synthesis
- in kinetic resolution of racemic 2-hydroxy-γ-butyrolactones with diphenylacetic acid
- as acylation and esterification reagent for anilines
- as acylation and esterification reagent for phenols
Uses A metabolite of a double prodrug (6-dGCV-DPiv
Flammability and Explosibility Not classified

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Trimethylacetic anhydride Spectrum

1538-75-6, Trimethylacetic anhydrideRelated Search:

Pharmaceuticals
Metabolites & Impurities
Intermediates & Fine Chemicals
Aliphatics
Aliphatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
有机原料
杂质对照品
抑制剂
精细化工原料
其它原料及中间体
高端化学
化工中间体
化工原料
有机化工原料
化工中间体
其他生化试剂
有机合成
中间体
氨基酸及其衍生物
小分子抑制剂
羧酸酐
Organic Building Blocks
Building Blocks
Carboxylic Acid Anhydrides
Carbonyl Compounds
CH33CCO2O
C10H18O3
特务酸酐
西维来司他钠杂质B-3(特戊酸酐)
阿德福韦酯杂质15(新戊酸酐)
阿德福韦杂质34
三甲基乙酸酐特戊酸酐
阿德福韦酯杂质18
新戊酸酐
1,3,5-三嗪,2-氯-4-(1-二苯并呋喃基)-6-苯基 -
特戊酸酐(无色透明液体
三甲基乙酸酐,99%
三甲基乙酸酐 100G
三甲基乙酸酐, >=98.0% (GC)
2,2-二甲基-丙酸酐
特戊酸酐
三甲基乙酸酐
1538-75-6
Cevelestat sodium impurity B-3 (valeanhydride)
Pivalic anhydride,98%
Pivolic Anhydride
Pivalic anhydride (7CI, 8CI)
2,2-dimethylpropanoyl 2,2-dimethylpropanoate
PIVALIC ANHYDRIDE
2,2-Dimethylpropanoicanhydride
Pivalic anydride
Pivalic acid anhydride
Bis(pivalic)anhydride
Bis(2,2-dimethylpropionic)anhydride
TIANFU-CHEM -TRIMETHYLACETIC ANHYDRIDE
Adefovir Dipivoxyl Impurity 18
Trimethylacetic Anhydride1538-75-6
Adefovir Impurity 36