ChemicalBook > CAS DataBase List > 2,4-Dinitrofluorobenzene

2,4-Dinitrofluorobenzene

CAS No.70-34-8
Chemical Name:2,4-Dinitrofluorobenzene
CBNumber:CB9442373
Molecular Formula:C6H3FN2O4
Formula Weight:186.1
MOL File:70-34-8.mol

2,4-Dinitrofluorobenzene Property

Melting point 25-27 °C (lit.)
Boiling point 178 °C/25 mmHg (lit.)
Density 1.482 g/mL at 25 °C (lit.)
refractive index n20/D 1.569(lit.)
Flash point >230 °F
storage temp. 2-8°C
solubility chloroform: 0.1 g/mL, clear
form Liquid or Low Melting Crystals
color Yellow to brownish
Specific Gravity 1.482
Water Solubility 400 mg/L (25 ºC)
Merck 14,4172
BRN 398632
Stability Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference 70-34-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII D241E059U6
NIST Chemistry Reference Benzene, 1-fluoro-2,4-dinitro-(70-34-8)
EPA Substance Registry System 2,4-Dinitrofluorobenzene (70-34-8)
UNSPSC Code 12352204
NACRES NA.83

Safety

Hazard Codes :C,T,Xn
Risk Statements :22-33-34-42/43-40-23/24/25-43-36/38-36/37/38
Safety Statements :22-26-36/37/39-45-28A-23-7/9-36/37
RIDADR :UN 3261 8/PG 2
WGK Germany :3
RTECS :CZ7800000
Hazard Note :Toxic
TSCA :Yes
HazardClass :6.1
PackingGroup :III
HS Code :29049085
Hazardous Substances Data :70-34-8(Hazardous Substances Data)

NFPA 704:

	1
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H317-H319-H335-H373
Precautionary statements P280-P301+P312+P330-P302+P352-P305+P351+P338-P314

2,4-Dinitrofluorobenzene Price More Price(18)

Brand: Sigma-Aldrich(India)
Product number: D1529
Product name : 1-Fluoro-2,4-dinitrobenzene
Purity: ≥99%
Packaging: 10ML
Price: ₹13577.85
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: D1529
Product name : 1-Fluoro-2,4-dinitrobenzene
Purity: ≥99%
Packaging: 25ML
Price: ₹23463.2
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: D1529
Product name : 1-Fluoro-2,4-dinitrobenzene
Purity: ≥99%
Packaging: 100ML
Price: ₹64027.95
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 73177
Product name : 1-Fluoro-2,4-dinitrobenzene
Purity: for HPLC derivatization, LiChropur?, ≥99.0% (GC)
Packaging: 1G
Price: ₹4853
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 73177
Product name : 1-Fluoro-2,4-dinitrobenzene
Purity: for HPLC derivatization, LiChropur?, ≥99.0% (GC)
Packaging: 10X1G
Price: ₹31006.45
Updated: 2022/06/14
Buy: Buy

2,4-Dinitrofluorobenzene Chemical Properties,Usage,Production

Chemical Properties Yellow solid
Uses 1-Fluoro-2,4-dinitrobenzene is used to identify the amino acid sequence. It reacts with amino group of amino acids to yield dinitrophenyl-amino acids. It is also used in chromatographic methods. Further, it acts as an alkylating agent used in elucidating amino acid sequence in proteins.
Uses A substituted benzene use in polypeptide sequencing (also referred to as Sanger’s reagent). Used in the derivitization of primary amines. Shown to inhibit the reductase activity of mitochondrial b-c1 complex isolated from beef heart mitochondria.
Definition ChEBI: The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions.
General Description Clear yellow crystals or yellow crystalline solid.
Air & Water Reactions Slightly soluble in water.
Reactivity Profile Reacts with oxidizing agents . When air was admitted after vacuum evaporation of an ether peroxide solution, a violent explosion occurred. A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups.
Fire Hazard 2,4-Dinitrofluorobenzene is probably combustible.
Biochem/physiol Actions 1-Fluoro-2,4-dinitrobenzene is a contact-sensitizing hapten, commonly used in experimental studies on contact hypersensitivity, inducing itch model, and atopic dermatitis. Mast cell activation is a key step in the DNFB induced sensitivity. DNFB covalently binds to the N-terminal amino acid of the protein and aids in Sanger sequencing.
Contact allergens DNFB is a strong skin irritant and a universal contact allergen. It is used as an intermediate in the synthesis of pesticides and pharmaceuticals such as flurbiprofen, a chemical reagent, and as a topical sensitizer for the treatment of alopecia areata
Safety Profile Poison by ingestion,skin contact, and subcutaneous routes. A powerful irritant and vesicant. Mutation data reported. Solutions in ether may explode when evaporated* When heated to decomposition it emits highly toxic fumes of NOx and F-. See also NITRO E COMPOUNDS of AROMATIC HYDROCARBONS and FLUORIDES.
Purification Methods Crystallise the reagent from Et2O or EtOH. Distil it in a vacuum through a Todd Column (p 11). If it is to be purified by distillation in vacuo, the distillation unit must be allowed to cool before air is allowed into the apparatus; otherwise the residue carbonises spontaneously and an EXPLOSION may occur. The material is a skin irritant and may cause serious dermatitis. [Beilstein 5 IV 742.]