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Propargyl-PEG4-S-PEG4-t-butyl ester

Propargyl-PEG4-S-PEG4-t-butyl ester Structure
Propargyl-PEG4-S-PEG4-t-butyl ester
  • CAS No.2055041-18-2
  • Chemical Name:Propargyl-PEG4-S-PEG4-t-butyl ester
  • CBNumber:CB93163112
  • Molecular Formula:C26H48O10S
  • Formula Weight:552.72
  • MOL File:2055041-18-2.mol
Propargyl-PEG4-S-PEG4-t-butyl ester Property
  • Boiling point 586.8±50.0 °C(Predicted)
  • Density 1.084±0.06 g/cm3(Predicted)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Propargyl-PEG4-S-PEG4-t-butyl ester Chemical Properties,Usage,Production

  • Description Propargyl-PEG4-S-PEG4-t-butyl ester is a PEG linker containing a propargyl group and t-butyl group. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. t-butyl ester is a better leaving group compared to a hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media.
  • Uses Propargyl-PEG4-S-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-S-PEG4-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • IC 50 PEGs
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Propargyl-PEG4-S-PEG4-t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Propargyl-PEG4-S-PEG4-t-butyl ester Suppliers
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Propargyl-PEG4-S-PEG4-t-butyl ester Spectrum
2055041-18-2, Propargyl-PEG4-S-PEG4-t-butyl esterRelated Search:
  • 中间体化合物
  • C26H48O10S
  • 丙炔-四聚乙二醇-硫-四聚乙二醇-叔丁酯
  • 炔基-四聚乙二醇-S-四聚乙二醇-叔丁酯
  • 2055041-18-2
  • 4,7,10,13,19,22,25,28-Octaoxa-16-thiahentriacont-30-ynoic acid, 1,1-dimethylethyl ester
  • Propargyl-PEG4-S-PEG4-Boc
  • Propargyl-PEG4-S-PEG4-t-butyl ester

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