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Propargyl-PEG4-S-PEG4-acid

Propargyl-PEG4-S-PEG4-acid Structure
Propargyl-PEG4-S-PEG4-acid
  • CAS No.2055041-20-6
  • Chemical Name:Propargyl-PEG4-S-PEG4-acid
  • CBNumber:CB33163110
  • Molecular Formula:C22H40O10S
  • Formula Weight:496.61
  • MOL File:2055041-20-6.mol
Propargyl-PEG4-S-PEG4-acid Property
  • Boiling point 591.5±50.0 °C(Predicted)
  • Density 1.141±0.06 g/cm3(Predicted)
  • pka 4.28±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Propargyl-PEG4-S-PEG4-acid Chemical Properties,Usage,Production

  • Description Propargyl-PEG4-S-PEG4-acid is a PEG linker containing a propargyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The hydrophilic PEG spacer increases solubility in aqueous media.
  • Uses Propargyl-PEG4-S-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-S-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • IC 50 PEGs
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Propargyl-PEG4-S-PEG4-acid Preparation Products And Raw materials
Raw materials
Preparation Products
Propargyl-PEG4-S-PEG4-acid Suppliers
Global(17)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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    Nextpeptide Inc
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  • Supplier：
    Aladdin Scientific
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  • Email：tp@aladdinsci.com
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Propargyl-PEG4-S-PEG4-acid Spectrum
2055041-20-6, Propargyl-PEG4-S-PEG4-acidRelated Search:
  • C22H40O10S
  • 丙炔-四聚乙二醇-硫-四聚乙二醇-羧酸
  • 炔基-四聚乙二醇-S-四聚乙二醇-羧酸
  • 2055041-20-6
  • 3-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethylsulfanyl]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
  • 4,7,10,13,19,22,25,28-Octaoxa-16-thiahentriacont-30-ynoic acid
  • Propargyl-PEG4-S-PEG4-acid

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