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FLECAINIDE ACETATE

FLECAINIDE ACETATE Structure
FLECAINIDE ACETATE
  • CAS No.54143-56-5
  • Chemical Name:FLECAINIDE ACETATE
  • CBNumber:CB9295801
  • Molecular Formula:C19H24F6N2O5
  • Formula Weight:474.39
  • MOL File:54143-56-5.mol
FLECAINIDE ACETATE Property
  • Melting point 145-147℃
  • storage temp. 2-8°C
  • solubility Soluble in water and in anhydrous ethanol. It is freely soluble in dilute acetic acid and practically insoluble in dilute hydrochloric acid.
  • form Solid
  • color White
  • Water Solubility Soluble in dilute acetic acid, dimethyl sulfoxide, ethanol, methanol and water.
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
  • EWG's Food Scores 1
  • FDA UNII M8U465Q1WQ
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22-36/37/38-63
  • Safety Statements  :22-26-36/37/39-45-46
  • RIDADR  :3249
  • WGK Germany  :-
  • RTECS  :CV5792550
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :2933399090
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H302-H315-H319-H335-H360FD
  • Precautionary statements P201-P202-P301+P312-P302+P352-P305+P351+P338-P308+P313
FLECAINIDE ACETATE Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: F6777
  • Product name : Flecainide acetate salt
  • Purity: 
  • Packaging: 25MG
  • Price: ₹14083.33
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: PHR2921
  • Product name : Flecainide Acetate
  • Purity: pharmaceutical secondary standard, certified reference material
  • Packaging: 500MG
  • Price: ₹18478.28
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: F6777
  • Product name : Flecainide acetate salt
  • Purity: 
  • Packaging: 100MG
  • Price: ₹48247.03
  • Updated: 2022/06/14
  • Buy: Buy

FLECAINIDE ACETATE Chemical Properties,Usage,Production

  • Description Flecainide acetate (54143-56-5) is an open Na+?channel blocker that inhibits fast Na+?current in cardiac muscle in a use- and concentration-dependent manner.1?Orally-active class Ic antiarrhythmic agent2,3. Inhibits hERG potassium channels at clinically relevant concentrations.4
  • Chemical Properties White or almost white, very hygroscopic, crystalline powder.
  • Uses Flecainide acetate is used as a sodium channel blocker and as an anti-arrhythmic. In general, it is used to regulate heartbeats of the upper heart and lower heart chambers. It can also be used to slow down an overactive heart. It is also useful in the treatment of ventricular tachycardias and ventricular arrhythmias.
  • Uses Class I antiarrhythmic.
  • Definition ChEBI: An acetate salt obtained by combining flecainide with one molar equivalent of acetic acid. An antiarrhythmic agent used to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).
  • brand name Tambocor (3M Pharmaceuticals).
  • General Description Flecainide acetate, N-(2-piperidinylmethyl)-2,5-bis (2,2,2-trifluoroethoxy)benzamide monoacetate(Tambocor), is a class IC antiarrhythmic drug withlocal anesthetic activity; it is a chemical derivative of benzamide.The drug undergoes biotransformation, forming ameta-O-dealkylated compound, whose antiarrhythmic propertiesare half as potent as those of the parent drug, and ameta-O-dealkylated lactam of flecainide with little pharmacologicalactivity. Flecainide acetate is given orally to suppresschronic ventricular ectopy and ventricular tachycardia.It has some limitations because of CNS side effects.
  • Biological Activity Open Na + channel blocker that inhibits fast Na + current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.
  • Biochem/physiol Actions Class IC antiarrhythmic agent; sodium channel blocker
  • Drug interactions Potentially hazardous interactions with other drugs
    Anti-arrhythmics: concentration increased by amiodarone - halve dose of flecainide; increased myocardial depression with other anti-arrhythmics.
    Antidepressants: concentration increased by fluoxetine; increased risk of ventricular arrhythmias with tricyclics.
    Antihistamines: increased risk of ventricular arrhythmias with mizolastine - avoid.
    Antihypertensives: increased myocardial depression and bradycardia with beta-blockers; increased myocardial depression and asystole with verapamil.
    Antimalarials: concentration increased by quinine; avoid with artemether/lumefantrine.
    Antimuscarinics: increased risk of ventricular arrhythmias with tolterodine.
    Antipsychotics: increased risk of ventricular arrhythmias with antipsychotics that prolong the QT interval and phenothiazines; increased risk of arrhythmias with clozapine.
    Antivirals: concentration possibly increased by fosamprenavir, indinavir, lopinavir, ritonavir and saquinavir, increased risk of ventricular arrhythmias - avoid; use telaprevir with caution.
    Diuretics: increased cardiac toxicity if hypokalaemia occurs.
  • Metabolism Flecainide is extensively metabolised (subject to genetic polymorphism), the 2 major metabolites being m-Odealkylated flecainide and m-O-dealkylated lactam of flecainide, both of which may have some activity. Its metabolism appears to involve the cytochrome P450 isoenzyme CYP2D6, which shows genetic polymorphism.
    Flecainide is excreted mainly in the urine, approximately 30% as unchanged drug and the remainder as metabolites. About 5% is excreted in the faeces. Haemodialysis removes only about 1% of unchanged flecainide.
  • storage Desiccate at +4°C
  • References 1) Rouet and Ducouret (1994), Use- and concentration-dependent effects of flecainide in guinea pig right ventricular muscle; J. Cardiovasc. Pharmacol.,?24?177 2) Singh?et al. (1984),?The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions; Ann. N.Y. Acad. Sci.,?432?210 3) Banitt?et al.?(1977),?Anti-arrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides; J. Med. Chem.,?20?821 4) Melgari?et al.?(2015),?Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide; J. Mol. Cell. Cardiol.,?86?42
FLECAINIDE ACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
FLECAINIDE ACETATE Suppliers
Global(220)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
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    career henan chemical co
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    TargetMol Chemicals Inc.
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    AFINE CHEMICALS LIMITED
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  • Email：info@finetechnology-ind.com
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FLECAINIDE ACETATE Spectrum
54143-56-5, FLECAINIDE ACETATERelated Search:
  • Organics
  • 抑制剂
  • 药物分子
  • 中间体
  • 原料药
  • Ion Channels
  • Monovalent Ion Channels
  • Voltage-gated Ion Channels
  • Sodium Channel Modulators
  • Other Sodium Channel Modulators
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • C19H24F6N2O5
  • C17H20F6N2O3C2H4O
  • C17H20F6N2O3C2H4O2
  • C17H20F6N2O2CH3COOH
  • 54153-56-5
  • 氟卡胺,10 MM DMSO 溶液
  • 醋酸氟卡尼/A1A
  • N-(哌啶-2-基甲基)-2,5-双(2,2,2-三氟乙氧基)苯甲酰胺乙酸盐
  • 醋酸氟卡尼盐
  • 氟卡尼 乙酸盐
  • 醋酸氟卡尼 EP标准品
  • 醋酸氟卡尼 USP标准品
  • 氟卡尼系统适应性 EP标准品
  • 氟卡尼醋酸盐
  • 乙酸氟卡尼
  • 醋酸氟卡尼
  • 醋酸洗必太
  • 醋酸洗必太/ 醋酸氟卡尼/乙酸氟卡尼/ N-(哌啶-2-基甲基)-2,5-二(2,2,2-三氟乙氧基)苯甲酰胺乙酸盐
  • 醋酸氟卡胺
  • 54143-56-5
  • FLECAINIDE ACETATE USP
  • Flecainide acetate, 10 mM in DMSO
  • N-(Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide acetate
  • Flecainide acetate N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2- trifluoroethoxy)benzamide acetate
  • Tambocor
  • Apocard
  • FLAC
  • Flecainide Acetate (1270800)
  • Flecainide for system suitability (Y0001274)
  • Flecainide acetateQ: What is Flecainide acetate Q: What is the CAS Number of Flecainide acetate Q: What is the storage condition of Flecainide acetate Q: What are the applications of Flecainide acetate
  • Flecainide acetate (F0120000)
  • FLECAINIDE ACETATE USP/EP/BP
  • N-[(RS)-(Piperidin-2-ylmethyl)]-2,5-bis(2,2,2- trifluoroethoxy)benzamide acetate
  • Flecainide for system suitability CRS
  • Flecainide acetate CRS
  • N-[[(2S)-2-piperidin-1-iumyl]methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • Flucarney Acetate
  • Flecainide for system suitability
  • Flecainide-d4 Acetate
  • Flecainide Acetate (200 mg)
  • Flecainide acetate salt,N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate salt
  • Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, monoacetate
  • Ecrinal
  • Almarytm
  • 2,5-Bis(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)benzamide acetate

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