ChemicalBook > CAS DataBase List > CASPASE-8 INHIBITOR II

CASPASE-8 INHIBITOR II

CASPASE-8 INHIBITOR II Structure
CASPASE-8 INHIBITOR II
  • CAS No.210344-98-2
  • Chemical Name:CASPASE-8 INHIBITOR II
  • CBNumber:CB9280050
  • Molecular Formula:C30H43FN4O11
  • Formula Weight:654.68
  • MOL File:Mol file
CASPASE-8 INHIBITOR II Property
  • Boiling point 925.7±65.0 °C(Predicted)
  • Density 1.247±0.06 g/cm3(Predicted)
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • solubility Soluble in DMSO
  • form Powder
  • pka 11.12±0.46(Predicted)
  • color White to light yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

CASPASE-8 INHIBITOR II Chemical Properties,Usage,Production

  • Uses A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B.
  • Biological Activity z-ietd-fmk is an inhibitor of caspase 8 [1].z-ietd-fmk inhibits t cell proliferation induced by pha or anti-cd3 plus anti-cd28 without toxicity of resting t cells. the mechanism of this inhibition of z-ietd-fmk has been proved not through the effect on il-2 secretion or ifn-γ production but the decrease of cd25 expression. experiments show that z-ietd-fmk has no effect on normal cell growth when there is no activation signal. z-ietd-fmk has also been found to significantly inhibit nf-κb activation when the concentration is 100μm [1].apart from the ability of inhibiting cell proliferation, z-ietd-fmk is reported to inhibit trail-mediated killing in cells. it protects the procaspases 9, 2, and 3, and protects parp to a similar extent in both hct116 and sw480 cells [2].
  • in vivo

    Pharmacological inhibition of caspase-8 by z-IETD-FMK robustly reduces tumor growth and this is closely associated with a reduction in the release of pro-inflammatory cytokines, IL-6, TNF-α, IL-18, IL-1α, IL-33, but not IL-1β. Furthermore, inhibition of caspase-8 reduces the recruitment of innate suppressive cells, such as myeloid-derived suppressor cells, but not of regulatory T cells to lungs of tumor-bearing mice[4].

  • target caspase 8
  • IC 50 Caspase-8
  • References [1] c.p. lawrence, s.c. chow. suppression of human t cell proliferation by the caspase inhibitors, z-vad-fmk and z-ietd-fmk is independent of their caspase inhibition properties. toxicology and applied pharmacology. 2012, 265: 103-112.
    [2] nesrin özören, kunhong kim, timothy f. burns, et al. the caspase 9 inhibitor z-lehd-fmk protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. cancer research. 2000, 60: 6259-6265.
CASPASE-8 INHIBITOR II Preparation Products And Raw materials
Raw materials
Preparation Products
CASPASE-8 INHIBITOR II Suppliers
Global(138)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Nextpeptide Inc
  • Tel：+86-0571-81612335<br/>+8613336028439
  • Email：sales@nextpeptide.com
  • Country：China
  • ProdList：19908
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
  • Supplier：
    LEAPCHEM CO., LTD.
  • Tel：+86-852-30606658
  • Email：market18@leapchem.com
  • Country：China
  • ProdList：43340
  • Advantage：58
CASPASE-8 INHIBITOR II Spectrum
210344-98-2, CASPASE-8 INHIBITOR IIRelated Search:
  • Caspase/Related Products
  • Caspases/Apoptosis
  • 抑制剂
  • C30H43FN4O11
  • 210344-95-2
  • 化合物Z-IETD-FMK,10 MM DMSO 溶液
  • 化合物Z-IETD-FMK
  • CASPASE-8抑制剂
  • (5S,8S,11S,14S)-5-((S)-仲丁基)-14-(2-氟乙酰基)-11-((R)-1-羟乙基)-8-(3-甲氧基-3-氧代丙基)-3,6,9,12-四氧代-1-苯基-2-氧杂-4,7,10,13-四氮杂十六烷-16-酸甲酯
  • 210344-98-2
  • Z-IETD-FMK, 10 mM in DMSO
  • methyl (3S)-3-[(2S,3R)-2-[(2S)-2-[(2S,3S)-2-{[(benzyloxy)carbonyl]amino}-3-methylpentanamido]-5-methoxy-5-oxopentanamido]-3-hydroxybutanamido]-5-fluoro-4-oxopentanoate
  • inhibit,Inhibitor,Caspase,Z IETD FMK,ZIETDFMK
  • Z-IETD-FMK
  • L-Threoninamide, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester
  • Z-IETD-FMK?, >98%
  • CASPASE-8 INHIBITOR;Z-IE(OME)TD(OME)-FMK
  • Z-IE(OME)TD(OME)-FMK
  • Z-IE(OME)TD(OME)-FLUOROMETHYLKETONE
  • Z-ILE-GLU(OME)-THR-DL-ASP(OME)-FLUOROMETHYLKETONE
  • Z-ILE-GLU(OME)-THR-ASP(OME)-FMK
  • Z-ILE-GLU(OME)-THR-ASP(OME)-FLUOROMETHYLKETONE
  • CASPASE-3 PROCESSING ENZYME INHIBITOR (FLUOROMETHYLKETONE)
  • CASPASE-8 INHIBITOR II
  • GRANZYME B INHIBITOR III
  • BENZYLOXYCARBONYL-ILE-GLU(OME)-THR-ASP(OME)-FLUOROMETHYLKETONE

Home

My