ChemicalBook > CAS DataBase List > Z-Vad-fmk, non-methylated

Z-Vad-fmk, non-methylated

Z-Vad-fmk, non-methylated Structure
Z-Vad-fmk, non-methylated
  • CAS No.161401-82-7
  • Chemical Name:Z-Vad-fmk, non-methylated
  • CBNumber:CB42497499
  • Molecular Formula:C21H28FN3O7
  • Formula Weight:453.46
  • MOL File:161401-82-7.mol
Z-Vad-fmk, non-methylated Property
  • Boiling point 758.0±60.0 °C(Predicted)
  • Density 1.260±0.06 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM)
  • pka 3.91±0.19(Predicted)
  • form Off-white solid
  • color White to light yellow
  • UNSPSC Code 12352209
  • NACRES NA.77
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338
Z-Vad-fmk, non-methylated Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: 219007
  • Product name : Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem
  • Purity: Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.
  • Packaging: 250μG
  • Price: ₹10670
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 219007
  • Product name : Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem
  • Purity: Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.
  • Packaging: 1MG
  • Price: ₹31630.01
  • Updated: 2022/06/14
  • Buy: Buy

Z-Vad-fmk, non-methylated Chemical Properties,Usage,Production

  • Description Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. This non-methylated form is useful in studies involving recombinant, isolated, or purified enzymes. Unlike the methylated form, Z-VAD(OMe)-FMK , this compound does not require pretreatment with esterases prior to in vitro use.
  • Uses Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM[1].
  • General Description An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 μl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available.
  • Biochem/physiol Actions Product does not compete with ATP.
  • IC 50 Caspase
  • References [1] Davies CW, et al. The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). Bioorg Med Chem Lett. 2012 Jun 15;22(12):3900-4. DOI:10.1016/j.bmcl.2012.04.124
    [2] Liu HR, et al. Antiproliferative activity of the total saponin of Solanum lyratum Thunb in Hela cells by inducing apoptosis. Pharmazie. 2008 Nov;63(11):836-42. PMID:19069247
Z-Vad-fmk, non-methylated Preparation Products And Raw materials
Raw materials
Preparation Products
Z-Vad-fmk, non-methylated Suppliers
Global(75)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
  • Supplier：
    LEAPCHEM CO., LTD.
  • Tel：+86-852-30606658
  • Email：market18@leapchem.com
  • Country：China
  • ProdList：43340
  • Advantage：58
  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：57505
  • Advantage：58
Z-Vad-fmk, non-methylated Spectrum
161401-82-7, Z-Vad-fmk, non-methylatedRelated Search:
  • 化学试剂
  • 抑制剂
  • 药靶配体
  • Caspase 抑制剂
  • C21H28FN3O7
  • Z-VAD(OH)-FMK(半胱天冬酶抑制剂VI)
  • 化合物Z-VAD(OH)-FMK,10 MM DMSO 溶液
  • CASPASE抑制剂VI CALBIOCHEM
  • 化合物Z-VAD(OH)-FMK
  • (5S,8S,11S)-11-(2-氟乙酰基)-5-异丙基-8-甲基-3,6,9-三氧代-1-苯基-2-氧杂-4,7,10-三氮杂十三烷13-酸
  • PAN-CASPASE抑制剂
  • 161401-82-7
  • Z-VAD-FMK, 10 mM in DMSO
  • inhibit,Inhibitor,ZVADFMK,Hela,Z VAD FMK,Caspase,Antiapoptosis,cells,pan-caspase
  • Z-VAD
  • (5S,8S,11S)-11-(2-Fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oic acid
  • abs817872
  • Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem
  • Z-VAD(OH)-FMK (Caspase Inhibitor VI)
  • Z-VAD-FMK, Free Acid
  • L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[1-(carboxymethyl)-3-fluoro-2-oxopropyl]-, (S)-
  • L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]- (9ci)
  • L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-
  • Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone
  • Z-VAD-FMK (Caspase Inhibitor VI)
  • Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE

Home

My