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Argipressine

CAS No.113-79-1
Chemical Name:Argipressine
CBNumber:CB9205622
Molecular Formula:C46H65N15O12S2
Formula Weight:1084.24
MOL File:113-79-1.mol

Argipressine Property

Density 1.59±0.1 g/cm3(Predicted)
Flash point 113℃
storage temp. 2-8°C
pka 9.90±0.15(Predicted)
form Solid
color White to off-white
PH ~3.5
optical activity -23.822 (1 mol dm-3 acetic acid)
biological source synthetic (organic)
Water Solubility Water : ≥ 360 mg/mL (332.03 mM)
Sequence H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2，(Disulfide bond)
InChIKey KBZOIRJILGZLEJ-KIIOGHSHNA-N
EWG's Food Scores 1
FDA UNII 4R069M4O1P
UNSPSC Code 51111800
NACRES NA.32

Safety

Hazard Codes :Xn
Risk Statements :20
Safety Statements :36
WGK Germany :3
HS Code :2937190000
Toxicity :TDLo ivn-pig: 40 ng/kg JPETAB 293,852,2000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H332
Precautionary statements P261

Argipressine Price More Price(5)

Brand: Sigma-Aldrich(India)
Product number: V9879
Product name : [Arg8]-Vasopressin acetate salt
Purity: ≥95% (HPLC)
Packaging: 1MG
Price: ₹8779.08
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: V9879
Product name : [Arg8]-Vasopressin acetate salt
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: ₹31035.28
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: V9879
Product name : [Arg8]-Vasopressin acetate salt
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: ₹125472.58
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: V0377
Product name : [Arg8]-Vasopressin solution
Purity: Grade VI (synthetic), ~100?IU/mL in 0.9% NaCl
Packaging: 50IU
Price: ₹9969.83
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: V0377
Product name : [Arg8]-Vasopressin solution
Purity: Grade VI (synthetic), ~100?IU/mL in 0.9% NaCl
Packaging: 100IU
Price: ₹16843.7
Updated: 2022/06/14
Buy: Buy

Argipressine Chemical Properties,Usage,Production

Uses Hormone (antidiuretic).
Uses [Arg⁸]-Vasopressin solution was used as an antigen for preparing preadsorbed antisera for immunocytochemistry. The product was used in L6 cell culture of the C5 subclone for differentiation studies.
Definition ChEBI: The predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.
Indications ADH (vasopressin) is released primarily in response to increases in plasma osmolarity or decreases in blood volume. It produces its antidiuretic activity in the kidney, causing the cortical and medullary parts of the collecting duct to become more permeable to water, thereby increasing water reabsorption, reducing serum osmolarity, and increasing its volume. It produces this effect by binding to a subset of vasopressin receptors called V₂ that have relatively high affinity for the hormone. ADH also has actions at sites other than the kidney. V₂ receptors also mediate an increase in circulating levels of two proteins involved in blood coagulation: factor VIII and von Willebrand’s factor.At higher concentrations, ADH interacts with V1 receptors to cause a general constriction of most blood vessels. It also interacts with V₃ (or V_1b) receptors to increase ACTH release, although the major control of ACTH release occurs through corticotropin-releasing hormone.
brand name Pitressin (Parke-Davis).
General Description Vasopressin tannate (PitressinTannate) is a water-insoluble tannate of vasopressin administeredintramuscularly (1.5–5.0 pressor units daily)for its prolonged duration of action by the slow release ofvasopressin. It is particularly useful for patients who havediabetes insipidus, but it should never be used intravenously.
Hazard A poison.
Biochem/physiol Actions [Arg8]-Vasopressin solution also known as Antidiuretic hormone, Arginine vasopressin or beta-Hypophamine is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It stimulates three acid-base transporters and hence increases the capability of the cell to regulate pH.
Mechanism of action ADH itself is available for injections (Pitressin) but has a half-life of about 15 minutes. Desmopressin (DDAVP) is an analogue without an amino group at the first amino acid and with D-arginine instead of Larginine. This analogue is more stable and has very little pressor activity. Desmopressin can be given subcutaneously or nasally, and the effects last for 12 hours.
Clinical Use Because it is stable, desmopressin is preferred for treatments especially if pressor effects are not desired. The primary indication for therapy is central diabetes insipidus, a disorder that results when ADH secretion is reduced and that is characterized by polydipsia, polyuria, and dehydration. Desmopressin is also used to reduce primary nocturnal enuresis, or bedwetting, in children. It is useful in people with mild hemophilia A or with some types of von Willebrand’s disease, in which von Willebrand’s factor is present at low levels. In these cases, desmopressin is given when excessive bleeding occurs or before surgery to help reduce bleeding indirectly by increasing the amounts of coagulation factors. A possible adverse effect of desmopressin is water intoxication if too much is taken.
ADH antagonists, including nonpeptide analogues that may be taken orally, have been developed with specificity for each of the receptor types. In the future, those that block V1 receptors may be useful in treating hypertension, and those that block V2 receptors may be useful in any condition of excessive water retention or hyponatremia, for which so far there is no satisfactory therapeutic treatment.
Safety Profile A poison by intravenous route.When heated to decomposition it emits toxic vapors ofNOx and SOx.
storage Store at -20°C